Cross‐talk between neurosteroid and endocannabinoid systems in cannabis addiction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13191
Abstract: Steroids and endocannabinoids are part of two modulatory systems and some evidence has shown their interconnections in several functions. Homeostasis is a common steady‐state described in the body, which is settled by regulatory systems to… read more here.
Keywords: neurosteroid endocannabinoid; cross talk; pregnenolone; systems cannabis ... See more keywords
The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of endocrinology"
DOI: 10.1530/eje-19-0352
Abstract: OBJECTIVE Previous studies have uncovered a progestin-only contraceptive association with an increased risk of diabetes, but limited study has explored the relationship of endogenous progesterone and pregnenolone level with diabetes status. A case-control study was… read more here.
Keywords: progesterone pregnenolone; pregnenolone; dose response; chinese rural ... See more keywords
Genomic and non-genomic effects of progesterone and pregnenolone on the function of bovine endometrial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinarni Medicina"
DOI: 10.17221/58/2009-vetmed
Abstract: Progesterone (P 4 ) decreases oxytocin (OT)-stimulated prostaglandin (PG)F 2α , but not PGE 2 secre- tion from bovine endometrial cells and this effect is partly elicited via a non-genomic route. The aim of this… read more here.
Keywords: genomic non; non genomic; endometrial cells; pregnenolone ... See more keywords
Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production
Sign Up to like & getrecommendations! Published in 2024 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2023.032
Abstract: Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (22:6n-3, DHA), play crucial roles in the reproductive health of vertebrates, including humans. Nevertheless, the underlying mechanism related to this phenomenon remains largely unknown. In this… read more here.
Keywords: oocyte maturation; pregnenolone; acid dha; dha ... See more keywords
Pregnenolone protects the liver against doxorubicin-induced cellular injury by anti-inflammatory, antioxidant, and antiapoptotic mechanisms: role of Keap1/Nrf2/HO-1 and P-glycoprotein.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202305_32484
Abstract: OBJECTIVE Doxorubicin (DOX) is a widely used cytotoxic anthracycline antibiotic characterized by increased adverse effects that limit its clinical usefulness. Pregnenolone is a pregnane X receptor (PXR) agonist that increases the expression of xenobiotic transporters… read more here.
Keywords: inflammatory antioxidant; dox; dox induced; pregnenolone ... See more keywords
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Sign Up to like & getrecommendations! Published in 2024 at "Life"
DOI: 10.3390/life14111483
Abstract: Substance use disorders (SUDs), including cocaine use disorder (CUD), have significant negative health risks and impose a substantial social burden, yet effective treatments are limited. Pregnenolone, a neuroactive steroid precursor, has been shown to reduce… read more here.
Keywords: pregnenolone; cocaine use; pregnenolone levels; plasma pregnenolone ... See more keywords