Evidence that preimmunization with a heat-killed preparation of Mycobacterium vaccae reduces corticotropin-releasing hormone mRNA expression in the extended amygdala in a fear-potentiated startle paradigm
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.12.015
Abstract: Posttraumatic stress disorder (PTSD) is a trauma and stressor-related disorder that is characterized by dysregulation of glucocorticoid signaling, chronic low-grade inflammation, and impairment in the ability to extinguish learned fear. Corticotropin-releasing hormone (Crh) is a… read more here.
Keywords: preimmunization; fear; corticotropin releasing; vaccae ... See more keywords
Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aay8924
Abstract: Transcriptomic signatures before and after immunization predict protection against malaria induced by sporozoite and RTS,S/AS01E immunization. Predicting protection A highly effective malaria vaccine would save many lives but correlates of protection remain ill-defined. Moncunill et… read more here.
Keywords: protection; immunization; trial; preimmunization ... See more keywords