Single‐cell analysis of nonhuman primate preimplantation development in comparison to humans and mice
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.295
Abstract: Genetic programs underlying preimplantation development and early lineage segregation are highly conserved across mammals. It has been suggested that nonhuman primates would be better model organisms for human embryogenesis, but a limited number of studies… read more here.
Keywords: preimplantation; cell analysis; single cell; preimplantation development ... See more keywords
PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30362
Abstract: Parathyroid hormone‐related protein (PTHrP), the main cause of humoral hypercalcemia in malignancies, promotes cell proliferation and delays terminal cell maturation during embryonic development. Our previous study reported that PTHrP plays important roles in blastocyst formation,… read more here.
Keywords: pthrp; hdac4; embryonic development; preimplantation ... See more keywords
Novel key roles for structural maintenance of chromosome flexible domain containing 1 (Smchd1) during preimplantation mouse development
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23001
Abstract: Structural maintenance of chromosome flexible domain containing 1 (Smchd1) is a chromatin regulatory gene for which mutations are associated with facioscapulohumeral muscular dystrophy and arhinia. The contribution of oocyte‐ and zygote‐expressed SMCHD1 to early development… read more here.
Keywords: flexible domain; structural maintenance; preimplantation; chromosome flexible ... See more keywords
Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Preimplantation Embryos.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7780-2_19
Abstract: The use of time-lapse microscopic imaging has proven to be a powerful tool for the study of mitotic divisions and other cellular processes across diverse species and cell types. Although time-lapse monitoring (TLM) of human… read more here.
Keywords: embryos; time; preimplantation; chromosomal abnormalities ... See more keywords
Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-021-03530-8
Abstract: First cell fate determination plays crucial roles in cell specification during early phases of embryonic development. Three classical concepts have been proposed to explain the lineage specification mechanism of the preimplantation embryo: inside-outside, pre-patterning, and… read more here.
Keywords: fate determination; preimplantation; cell fate; cell ... See more keywords
Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-020-01767-w
Abstract: The aim of the study is to investigate presence and role of the gene encoding the maternally contributed nucleotide-binding oligomerization domain (NOD)–like receptors with a pyrin domain (PYD)–containing protein 9 (NLRP9) in human and mouse… read more here.
Keywords: expressed human; human mouse; preimplantation; maternally contributed ... See more keywords
When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)—the consensus of two Italian scientific societies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-020-02015-x
Abstract: A clear definition of developmentally incompetent preimplantation embryo (DIPE) in literature is still missing, while several scientific societies are discussing this challenging topic. From both a clinical and scientific perspective, the identification of embryos unfit… read more here.
Keywords: embryology; embryos; genetics; preimplantation ... See more keywords
Clinical application of an NGS-based method in the preimplantation genetic testing for Duchenne muscular dystrophy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-021-02126-z
Abstract: To determine whether next-generation sequencing (NGS) could be used to directly detect different mutations of Duchenne muscular dystrophy (DMD) during preimplantation genetic testing (PGT). From Sep. 2016 to Aug. 2018, a total of six couples… read more here.
Keywords: genetic testing; muscular dystrophy; preimplantation; ngs based ... See more keywords
Low-dose Roundup induces developmental toxicity in bovine preimplantation embryos in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08183-8
Abstract: Roundup is a widely used glyphosate-based herbicide worldwide. Roundup residues can be detected in the organs and urine of animals. However, its toxicity on mammalian preimplantation embryos has not been well investigated. Here, we show… read more here.
Keywords: roundup; preimplantation embryos; preimplantation; toxicity ... See more keywords
Melatonin protect the development of preimplantation mouse embryos from sodium fluoride-induced oxidative injury.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.06.014
Abstract: Recently study shows that melatonin can protect embryos from the culture environment oxidative stress. However, the protective effect of melatonin on the mouse development of preimplantation embryos under sodium fluoride (NaF) induced oxidative stress is… read more here.
Keywords: induced oxidative; preimplantation; melatonin protect; development ... See more keywords
Epigenetic disruption of estrogen receptor alpha is induced by a glyphosate-based herbicide in the preimplantation uterus of rats
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.10.022
Abstract: Previously, we have shown that perinatal exposure to a glyphosate-based herbicide (GBH) induces implantation failures in rats. Estrogen receptor alpha (ERα) is critical for successful implantation. ERα transcription is under the control of five promoters… read more here.
Keywords: glyphosate based; receptor alpha; gbh; based herbicide ... See more keywords