JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.06.006
Abstract: JPH203 is a novel anti-cancer drug targeting L-type amino acid transporter 1 (LAT1), which plays a primary role in the uptake of essential amino acids in tumor cells. Although a co-incubation inhibitory effect of JPH203… read more here.
Keywords: preincubation inhibitory; amino; preincubation; function ... See more keywords
Research Note: Effects of preincubation and higher initiating incubation temperature of long-term stored hatching eggs on hatchability and day-old chick and yolk sac weight
Sign Up to like & getrecommendations! Published in 2021 at "Poultry Science"
DOI: 10.1016/j.psj.2021.101293
Abstract: We studied the effect of increased initial incubation temperature and repeated preincubation of 35-d stored eggs from 46-week-old Ross 308 parental stock on the hatchability and day-old chick and yolk sac weight. Two different temperatures… read more here.
Keywords: temperature; preincubation; yolk sac; incubation ... See more keywords
Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions
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DOI: 10.3390/pharmaceutics15031020
Abstract: Impaired transport activity of hepatic OATP1B1 and OATP1B3 due to drug–drug interactions (DDIs) often leads to increased systemic exposure to substrate drugs (e.g., lipid-lowering statins). Since dyslipidemia and hypertension frequently coexist, statins are often concurrently… read more here.
Keywords: oatp1b1 oatp1b3; drug drug; oatp1b3 mediated; preincubation ... See more keywords