Abstract 914: Preinfusion polyfunctional profiles and cytokine secretion activity of transgenic TCR-T cells, and serum cytokine profiles, are associated with clinical outcomes in sarcoma and melanoma
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DOI: 10.1158/1538-7445.am2023-914
Abstract: Background: Transgenic TCR-T cells targeting MART-1 and NY-ESO-1 for the treatment of melanoma and sarcoma, respectively, are associated with robust initial clinical responses. However, these responses are often not durable, and a significant proportion of… read more here.
Keywords: cell; serum cytokine; tcr; preinfusion ... See more keywords
Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL.
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DOI: 10.1182/blood-2018-01-828343
Abstract: After treatment with chimeric antigen receptor (CAR) T cells, interleukin-15 (IL-15) elevation and CAR T-cell expansion are associated with non-Hodgkin lymphoma (NHL) outcomes. However, the association of preinfusion CAR product T-cell functionality with clinical outcomes… read more here.
Keywords: clinical outcomes; product; preinfusion; cell ... See more keywords