Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells International"
DOI: 10.1155/2020/3150716
Abstract: Aging is a predominant risk factor for many chronic conditions. Stem cell dysfunction plays a pivotal role in the aging process. Prelamin A, an abnormal processed form of the nuclear lamina protein lamin A, has… read more here.
Keywords: premature senescence; senescence; msc; stem ... See more keywords
Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies
Sign Up to like & getrecommendations! Published in 2019 at "JCI Insight"
DOI: 10.1172/jci.insight.126315
Abstract: Cardiomyopathies are complex heart muscle diseases that can be inherited or acquired. Dilated cardiomyopathy can result from mutations in LMNA, encoding the nuclear intermediate filament proteins lamin A/C. Some LMNA mutations lead to accumulation of… read more here.
Keywords: accumulation; mediates myocardial; prelamin mediates; inflammation ... See more keywords
Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ra119000593
Abstract: Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and… read more here.
Keywords: mice; adipose tissue; zmpste24; prelamin ... See more keywords