AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0518-9
Abstract: The prelimbic cortex (PL) is an important structure in the neural pathway integrating stress responses. Brain angiotensin is involved in cardiovascular control and modulation of stress responses. Blockade of angiotensin receptors has been reported to… read more here.
Keywords: response; at2 receptors; prelimbic cortex; stress ... See more keywords
Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.09.024
Abstract: BACKGROUND Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone "set… read more here.
Keywords: corticosterone; transmission; prelimbic cortex; drug ... See more keywords
Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling
Sign Up to like & getrecommendations! Published in 2022 at "Neuron"
DOI: 10.1016/j.neuron.2022.02.001
Abstract: Autism spectrum disorder (ASD) involves genetic and environmental components. The underlying circuit mechanisms are unclear, but behaviorally, aversion toward unfamiliarity, a hallmark of autism, might be involved. Here, we show that in Shank3ΔC/ΔC ASD model… read more here.
Keywords: exposure; mice; tail striatum; prelimbic cortex ... See more keywords
Prelimbic cortex miR-34a contributes to (2R,6R)-hydroxynorketamine-mediated antidepressant-relevant actions
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.108984
Abstract: The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has recently been suggested to exert fast-acting antidepressant-relevant actions and was proposed as an ideal next-generation antidepressant. However, the microRNA-mediated mechanism underlying its effects is still unknown. In the present… read more here.
Keywords: mir; relevant actions; mediated antidepressant; prelimbic cortex ... See more keywords
Inactivation of the prelimbic cortex attenuates operant responding in both physical and behavioral contexts
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2020.107189
Abstract: The present experiments aimed to expand our understanding of the role of the prelimbic cortex (PL) in the contextual control of instrumental behavior. Research has previously shown that the PL is involved when the "physical… read more here.
Keywords: first response; response; prelimbic cortex; inactivation ... See more keywords
The activity of the prelimbic cortex in rats is enhanced during the cooperative acquisition of an instrumental learning task
Sign Up to like & getrecommendations! Published in 2019 at "Progress in neurobiology"
DOI: 10.1016/j.pneurobio.2019.101692
Abstract: The objective of this study was to identify the functional properties of the prefrontal cortex that allow animals to work together to obtain a mutual reward. We induced pairs of male rats to develop a… read more here.
Keywords: activity prelimbic; task; cortex; prelimbic cortex ... See more keywords
Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories
Sign Up to like & getrecommendations! Published in 2017 at "Nature neuroscience"
DOI: 10.1038/nn.4443
Abstract: The ability to regulate the consolidation and strengthening of memories for threatening experiences is critical for mental health, and its dysregulation may lead to psychopathologies. Re-exposure to the context in which the threat was experienced… read more here.
Keywords: extinction; prelimbic cortex; dorsal hippocampal; direct dorsal ... See more keywords
Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.190
Abstract: Repeated binge-like exposure to alcohol during adolescence has been reported to perturb prefrontal cortical development, yet the mechanisms underlying these effects are unknown. Here we report that adolescent intermittent ethanol exposure induces cellular and dopaminergic… read more here.
Keywords: adolescence; exposure; prelimbic cortex; alcohol ... See more keywords
Prelimbic Cortex Deep Brain Stimulation Reduces Binge Size in a Chronic Binge Eating Rat Model
Sign Up to like & getrecommendations! Published in 2018 at "Stereotactic and Functional Neurosurgery"
DOI: 10.1159/000486965
Abstract: Background: Binge eating (BE) involves the consumption of a large amount of food in a short period of time and a loss of control during the binge episode. It is a key feature of the… read more here.
Keywords: binge size; stimulation; frequency; prelimbic cortex ... See more keywords
Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.59281
Abstract: The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance of danger, the PFC likely plays a role in selecting the optimal choice. In platform-mediated active avoidance,… read more here.
Keywords: cortex bidirectionally; divergent projections; avoidance; active avoidance ... See more keywords