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   Articles with "prelimbic cortex" as a keyword



AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats

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recommendations! Published in 2017 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-017-0518-9

Abstract: The prelimbic cortex (PL) is an important structure in the neural pathway integrating stress responses. Brain angiotensin is involved in cardiovascular control and modulation of stress responses. Blockade of angiotensin receptors has been reported to… read more here.

Keywords: response; at2 receptors; prelimbic cortex; stress ... See more keywords

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex

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recommendations! Published in 2018 at "Biological Psychiatry"

DOI: 10.1016/j.biopsych.2017.09.024

Abstract: BACKGROUND Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone "set… read more here.

Keywords: corticosterone; transmission; prelimbic cortex; drug ... See more keywords

Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling

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recommendations! Published in 2022 at "Neuron"

DOI: 10.1016/j.neuron.2022.02.001

Abstract: Autism spectrum disorder (ASD) involves genetic and environmental components. The underlying circuit mechanisms are unclear, but behaviorally, aversion toward unfamiliarity, a hallmark of autism, might be involved. Here, we show that in Shank3ΔC/ΔC ASD model… read more here.

Keywords: exposure; mice; tail striatum; prelimbic cortex ... See more keywords

Prelimbic cortex miR-34a contributes to (2R,6R)-hydroxynorketamine-mediated antidepressant-relevant actions

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recommendations! Published in 2022 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2022.108984

Abstract: The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has recently been suggested to exert fast-acting antidepressant-relevant actions and was proposed as an ideal next-generation antidepressant. However, the microRNA-mediated mechanism underlying its effects is still unknown. In the present… read more here.

Keywords: mir; relevant actions; mediated antidepressant; prelimbic cortex ... See more keywords
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Inactivation of the prelimbic cortex attenuates operant responding in both physical and behavioral contexts

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recommendations! Published in 2020 at "Neurobiology of Learning and Memory"

DOI: 10.1016/j.nlm.2020.107189

Abstract: The present experiments aimed to expand our understanding of the role of the prelimbic cortex (PL) in the contextual control of instrumental behavior. Research has previously shown that the PL is involved when the "physical… read more here.

Keywords: first response; response; prelimbic cortex; inactivation ... See more keywords

The activity of the prelimbic cortex in rats is enhanced during the cooperative acquisition of an instrumental learning task

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recommendations! Published in 2019 at "Progress in neurobiology"

DOI: 10.1016/j.pneurobio.2019.101692

Abstract: The objective of this study was to identify the functional properties of the prefrontal cortex that allow animals to work together to obtain a mutual reward. We induced pairs of male rats to develop a… read more here.

Keywords: activity prelimbic; task; cortex; prelimbic cortex ... See more keywords

Direct dorsal hippocampal-prelimbic cortex connections strengthen fear memories

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recommendations! Published in 2017 at "Nature neuroscience"

DOI: 10.1038/nn.4443

Abstract: The ability to regulate the consolidation and strengthening of memories for threatening experiences is critical for mental health, and its dysregulation may lead to psychopathologies. Re-exposure to the context in which the threat was experienced… read more here.

Keywords: extinction; prelimbic cortex; dorsal hippocampal; direct dorsal ... See more keywords

Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex

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recommendations! Published in 2017 at "Neuropsychopharmacology"

DOI: 10.1038/npp.2016.190

Abstract: Repeated binge-like exposure to alcohol during adolescence has been reported to perturb prefrontal cortical development, yet the mechanisms underlying these effects are unknown. Here we report that adolescent intermittent ethanol exposure induces cellular and dopaminergic… read more here.

Keywords: adolescence; exposure; prelimbic cortex; alcohol ... See more keywords

A distinct neuronal ensemble of prelimbic cortex mediates spontaneous pain in rats with peripheral inflammation

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-52243-3

Abstract: The absence of a comprehensive understanding of the neural basis of spontaneous pain limits the development of therapeutic strategies targeting this primary complaint of patients with chronic pain. Here we report a distinct neuronal ensemble… read more here.

Keywords: spontaneous pain; pain; neuronal ensemble; distinct neuronal ... See more keywords

Distinct prelimbic cortex ensembles encode response execution and inhibition.

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2505378122

Abstract: Learning when to initiate or withhold actions is essential for survival, requiring the integration of past experiences with new information to adapt to changing environments. The prelimbic cortex (PL) plays a central role in this… read more here.

Keywords: inhibition; response; response execution; prelimbic cortex ... See more keywords

Dysfunction of the paraventricular thalamus–prelimbic cortex circuit underlies maternal separation–induced deficits in contagious pain

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.ady1944

Abstract: Contagious pain is considered one of the most common forms of emotional contagion observed in animal models. Nevertheless, little is known about the precise neural mechanisms governing the regulation of contagious pain in response to… read more here.

Keywords: pain; contagious pain; paraventricular thalamus; prelimbic cortex ... See more keywords