Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3‐Substituted and 3‐Unsubstituted N‐[(4‐Arylpiperazin‐1‐yl)alkyl]pyrrolidine‐2,5‐dione Derivatives
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DOI: 10.1002/cmdc.201700539
Abstract: A new series of 1,3‐substituted pyrrolidine‐2,5‐dione derivatives as potential anticonvulsant agents are described. Initial pharmacological screening of these compounds was performed by using acute models of seizures (MES and scPTZ tests) in mice after intraperitoneal… read more here.
Keywords: pyrrolidine dione; dione; lipophilicity; dione derivatives ... See more keywords
Preliminary safety assessment of oridonin in zebrafish
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DOI: 10.1080/13880209.2019.1662457
Abstract: Abstract Context: Oridonin, isolated from the leaves of Isodon rubescens (Hemsl.) H.Hara (Lamiaceae), has good antitumor activity. However, its safety in vivo is still unclear. Objective: To investigate the preliminary safety of oridonin in zebrafish.… read more here.
Keywords: safety assessment; oridonin; hpf; oridonin zebrafish ... See more keywords
Preliminary safety, efficacy and pharmacokinetics (PK) results of KN026, a HER2 bispecific antibody in patients (pts) with HER2-positive metastatic breast cancer.
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DOI: 10.1200/jco.2020.38.15_suppl.1041
Abstract: 1041Background: KN026 is a novel bispecific antibody that simultaneously binds to two distinct HER2 epitopes, the same domains as trastuzumab (ECD4) and pertuzumab (ECD2). It blocks ligand-dependen... read more here.
Keywords: efficacy pharmacokinetics; safety efficacy; antibody; pharmacokinetics results ... See more keywords
Preliminary Safety Analysis of a Wearable Clinic for the Early Detection of Psychotic Relapse
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DOI: 10.3233/shti200445
Abstract: We discuss the preliminary safety analysis of a smartphone-based intervention for early detection of psychotic relapse. We briefly describe how we identified patient safety hazards associated with the system and how measures were defined to… read more here.
Keywords: detection psychotic; safety analysis; preliminary safety; psychotic relapse ... See more keywords