Crossbow Bioreactors for Studying the Effects of Time‐Varying Mechanical Preload and Afterload on Engineered Cardiac Tissues
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202519601
Abstract: Mechanical loading plays a critical role in heart development and function, with cardiac preload (tissue stretch during chamber filling) and afterload (resistance against which the heart works to eject blood) potentially playing distinct roles in… read more here.
Keywords: preload afterload; cardiac tissues; engineered cardiac; culture ... See more keywords
Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13877
Abstract: Pressure overload (PO) and volume overload (VO) lead to concentric or eccentric hypertrophy. Previously, we could show that activation of signalling cascades differ in in vivo mouse models. Activation of these signal cascades could either… read more here.
Keywords: different activation; preload afterload; activation mapks; akt gsk3 ... See more keywords
Detection of physiological control inputs preload and afterload from intrinsic pump parameters in total artificial heart.
Sign Up to like & getrecommendations! Published in 2022 at "Artificial organs"
DOI: 10.1111/aor.14481
Abstract: BACKGROUND In the total artificial heart (TAH), the inputs to the physiological control unit, preload, and afterload, are detected from intrinsic pump parameters (e.g., motor current). Within this study, their detection techniques are developed, and… read more here.
Keywords: preload afterload; total artificial; heart; preload ... See more keywords