The somatic mutation landscape of premalignant colorectal adenoma
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DOI: 10.1136/gutjnl-2016-313573
Abstract: Objective There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma.… read more here.
Keywords: mutation landscape; adenoma; somatic mutation; premalignant colorectal ... See more keywords
Mutation Profiling of Premalignant Colorectal Neoplasia
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DOI: 10.1155/2019/2542640
Abstract: Accumulation of allelic variants in genes that regulate cellular proliferation, differentiation, and apoptosis may result in expansion of the aberrant intestinal epithelium, generating adenomas. Herein, we compared the mutation profiles of conventional colorectal adenomas (CNADs)… read more here.
Keywords: lgd adenomas; profiling premalignant; grade dysplasia; mutation profiling ... See more keywords