Obesity as a premature aging phenotype - implications for sarcopenic obesity.
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DOI: 10.1007/s11357-022-00567-7
Abstract: Obesity and aging have both seen dramatic increases in prevalence throughout society. This review seeks to highlight common pathologies that present with obesity, along with the underlying risk factors, that have remarkable similarity to what… read more here.
Keywords: obesity premature; sarcopenic obesity; obesity; premature aging ... See more keywords
Premature Aging as an Accumulation of Deficits in Young Adult Survivors of Pediatric Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djac209
Abstract: BACKGROUND We aimed to characterize premature aging as an accumulation of deficits in survivors of pediatric cancer compared to community controls and examine associations with host/treatment factors, neurocognition, and mortality. METHODS Pediatric cancer survivors (N = 4,000,… read more here.
Keywords: pediatric cancer; accumulation; age; cancer ... See more keywords
Lysophosphatidic acid receptor LPA3 prevents oxidative stress and cellular senescence in Hutchinson–Gilford progeria syndrome
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DOI: 10.1111/acel.13064
Abstract: Hutchinson–Gilford progeria syndrome (HGPS) is a rare laminopathy that produces a mutant form of prelamin A, known as Progerin, resulting in premature aging. HGPS cells show morphological abnormalities of the nuclear membrane, reduced cell proliferation… read more here.
Keywords: hutchinson gilford; senescence; progeria syndrome; lysophosphatidic acid ... See more keywords
The E262K mutation in Lamin A links nuclear proteostasis imbalance to laminopathy‐associated premature aging
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DOI: 10.1111/acel.13688
Abstract: Deleterious, mostly de novo, mutations in the lamin A (LMNA) gene cause spatio‐functional nuclear abnormalities that result in several laminopathy‐associated progeroid conditions. In this study, exome sequencing in a sixteen‐year‐old male with manifestations of premature… read more here.
Keywords: laminopathy associated; e262k mutation; mutation; premature aging ... See more keywords
Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet
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DOI: 10.1111/acel.13760
Abstract: Aging‐associated microbial dysbiosis exacerbates various disorders and dysfunctions, and is a major contributor to morbidity and mortality in the elderly, but the underlying cause of this aging‐related syndrome is confusing. SIRT6 knockout (SIRT6 KO) mice… read more here.
Keywords: sirt6 mice; premature; high fat; premature aging ... See more keywords
Premature aging disorders: A clinical and genetic compendium
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DOI: 10.1111/cge.13837
Abstract: Progeroid disorders make up a heterogeneous group of very rare hereditary diseases characterized by clinical signs that often mimic physiological aging in a premature manner. Apart from Hutchinson‐Gilford progeria syndrome, one of the best‐investigated progeroid… read more here.
Keywords: genetics; premature; clinical genetic; disorders clinical ... See more keywords
Premature aging in mice with error-prone protein synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl9051
Abstract: The main source of error in gene expression is messenger RNA decoding by the ribosome. Translational accuracy has been suggested on a purely correlative basis to positively coincide with maximum possible life span among different… read more here.
Keywords: life span; mice error; error prone; aging mice ... See more keywords
Abstract PR08: Altered nucleolar trafficking of the Blm helicase in the mouse reduces size, increases DNA damage and tumor susceptibility, and facilitates premature aging
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DOI: 10.1158/1538-7445.mousemodels17-pr08
Abstract: Bloom9s syndrome (BS) is a recessive human chromosome breakage disorder caused by mutations in the recQ-like helicase BLM, sometimes known as RECQL2. Its clinical phenotype invariably includes male infertility, dwarfism, cancer susceptibility, and growth defects… read more here.
Keywords: tumor; susceptibility; trafficking blm; blm ... See more keywords
Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose
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DOI: 10.1182/blood.2022017594
Abstract: Patients with β -thalassemia show 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection, representing a high-risk population compared with age- and sex-matched healthy subjects. 1 Vaccination against SARS-CoV-2 is crucial to reduce mortality and… read more here.
Keywords: aging immune; cov mrna; vaccine; anti pf4 ... See more keywords
Identification and genetic analysis of EMS-mutagenized wheat mutants conferring lesion-mimic premature aging
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DOI: 10.1186/s12863-020-00891-x
Abstract: Background Lesion-mimic and premature aging ( lmpa ) mutant lmpa1 was identified from the ethyl methane sulfonate (EMS) mutant library in the bread wheat variety Keda 527 (KD527) background. To reveal the genetic basis of… read more here.
Keywords: kd527; wheat; analysis; lesion ... See more keywords
Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
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DOI: 10.1371/journal.pone.0205878
Abstract: Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the molecular mechanisms underlying… read more here.
Keywords: hutchinson gilford; cell lines; progeria syndrome; gilford progeria ... See more keywords