Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK- and ROS-mediated premature senescence
Sign Up to like & getrecommendations! Published in 2018 at "Biogerontology"
DOI: 10.1007/s10522-018-9753-9
Abstract: Tumor necrosis factor α (TNF-α) is an inflammatory mediator overexpressed in the skin as a response to ultraviolet radiation, as well as in chronic non-healing wounds. On the other hand, senescent fibroblasts have been shown… read more here.
Keywords: p38 mapk; premature senescence; tnf; exposure tnf ... See more keywords
Effect of sulfated galactan from Porphyra haitanensis on H2O2-induced premature senescence in WI-38 cells.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.08.123
Abstract: Porphyran sulfated galactan extracted from red algae Porphyra haitanensis is a sulfated polysaccharide, which possesses excellent activities. In the present study, WI-38 cells were treated with H2O2 to induce premature senescence and then the protection… read more here.
Keywords: premature senescence; porphyran; senescence; porphyra haitanensis ... See more keywords
Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.04.002
Abstract: Human dental pulp stem cells (hDPSCs) are a source for cell therapy. Before implantation, an in vitro expansion step is necessary, with the inconvenience that hDPSCs undergo senescence following a certain number of passages, loosing… read more here.
Keywords: human dental; premature senescence; senescence; oxidative stress ... See more keywords
Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells International"
DOI: 10.1155/2020/3150716
Abstract: Aging is a predominant risk factor for many chronic conditions. Stem cell dysfunction plays a pivotal role in the aging process. Prelamin A, an abnormal processed form of the nuclear lamina protein lamin A, has… read more here.
Keywords: premature senescence; senescence; msc; stem ... See more keywords
Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/8141307
Abstract: Globally, cardiovascular diseases are the leading cause of death in the aging population. While the clinical pathology of the aging heart is thoroughly characterized, underlying molecular mechanisms are still insufficiently clarified. The aim of the… read more here.
Keywords: premature senescence; cardiomyocyte contractility; contractility autophagy; senescence ... See more keywords
Regulation of Cr(VI)-Induced Premature Senescence in L02 Hepatocytes by ROS-Ca2+-NF-κB Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7295224
Abstract: Stress-induced premature senescence may be involved in the pathogeneses of acute liver injury. Hexavalent chromium [Cr(VI)], a common environmental pollutant related to liver injury, likely leads to premature senescence in L02 hepatocytes. However, the underlying… read more here.
Keywords: induced premature; senescence; premature senescence; l02 hepatocytes ... See more keywords
Effect of Ultraviolet B Irradiation on Melanin Content Accompanied by the Activation of p62/GATA4-Mediated Premature Senescence in HaCaT Cells
Sign Up to like & getrecommendations! Published in 2022 at "Dose-Response"
DOI: 10.1177/15593258221075321
Abstract: Objective To explore the effect and mechanism of ultraviolet B (UVB) on melanin synthesis and premature senescence in human immortalized keratinocytes (HaCaT) cells. Methods HaCaT cells were irradiated with 0, 20, 50, 80, 100, 150,… read more here.
Keywords: irradiation; gata4; senescence; p62 ... See more keywords
PPARδ Inhibits Hyperglycemia-Triggered Senescence of Retinal Pigment Epithelial Cells by Upregulating SIRT1
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11061207
Abstract: Emerging evidence shows that peroxisome proliferator-activated receptor delta (PPARδ) plays a pivotal role in cellular aging. However, its function in retinal disease processes such as hyperglycemia-associated diabetic retinopathy is unclear. Here, we demonstrate that PPARδ… read more here.
Keywords: ppar; senescence retinal; ppar inhibits; senescence ... See more keywords
Chrysanthemum coronarium L. Protects against Premature Senescence in Human Endothelial Cells
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DOI: 10.3390/cimb44120397
Abstract: The senescence of vascular endothelial cells (EC) leads to vascular dysfunction. However, the molecular mechanisms of EC senescence and its associated pathophysiological changes have not yet been clearly studied. This study sought to inspect the… read more here.
Keywords: huvecs; chrysanthemum coronarium; endothelial cells; senescence ... See more keywords
Antioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105750
Abstract: Mesenchymal stem cells (MSC) have many roles that are important for the body’s proper functioning. When the MSC pool is damaged, it is often correlated with impaired development or health of the organism. MSC are… read more here.
Keywords: heat shock; senescence; mesenchymal stem; stem cells ... See more keywords
Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H2O2-Induced Premature Senescence of Human Embryonic Lung Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169271
Abstract: N6-methyladenosine (m6A) methylation is one of the most common RNA modifications, regulating RNA fate at the posttranscriptional level, and is closely related to cellular senescence. Both models of replicative and premature senescence induced by hydrogen… read more here.
Keywords: m6a methylation; senescence; premature senescence;