Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B
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DOI: 10.1007/s12250-019-00179-0
Abstract: HIV-1 Rev is an accessory protein that plays a key role in nuclear exportation, stabilization, and translation of the viral mRNAs. Rev of HIV-1 clade BC often shows a truncation of 16 AAs due to… read more here.
Keywords: premature stop; rev; clade; stop codon ... See more keywords
Effect of Ataluren on dystrophin mutations
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DOI: 10.1111/jcmm.15319
Abstract: Duchenne muscular dystrophy is a severe muscle wasting disease caused by mutations in the dystrophin gene (dmd). Ataluren has been approved by the European Medicines Agency for treatment of Duchenne muscular dystrophy. Ataluren has been… read more here.
Keywords: effect; effect ataluren; premature stop; stop codons ... See more keywords
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon
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DOI: 10.1126/sciadv.adf2695
Abstract: Hundreds of pathogenic variants of mitochondrial DNA (mtDNA) have been reported to cause mitochondrial diseases, which still lack effective treatments. It is a huge challenge to install these mutations one by one. We repurposed the… read more here.
Keywords: rat; stop codon; premature stop; coding genes ... See more keywords
Hereditary angioedema caused by a premature stop codon mutation in the SERPING1 gene
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DOI: 10.1186/s13601-020-00360-9
Abstract: Hereditary angioedema with deficient and dysfunctional C1 inhibitor (C1-INH-HAE) is a rare genetic disorder. The majority of the cases with this disease are caused by mutations in the C1-inbitor gene SERPING1 and are classified as… read more here.
Keywords: premature stop; serping1 gene; hereditary angioedema; stop codon ... See more keywords
Efficient Simultaneous Introduction of Premature Stop Codons in Three Tumor Suppressor Genes in PFFs via a Cytosine Base Editor
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DOI: 10.3390/genes13050835
Abstract: Base editing is an efficient and precise gene-editing technique, by which a single base can be changed without introducing double-strand breaks, and it is currently widely used in studies of various species. In this study,… read more here.
Keywords: premature stop; stop codons; base; tri mut ... See more keywords