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Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.09.017
Abstract: HighlightsPremature termination codons are susceptible to constitutive readthrough.Readthrough compounds may restore synthesis of a functional full‐length protein.Mutations that alter splicing induce inappropriate inclusion or skipping of an exon.Oligonucleotide‐based therapies inhibit or activate specific splicing events.…
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Keywords:
codons repair;
termination codons;
suppression premature;
splicing mutations ... See more keywords
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Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.198176
Abstract: ABSTRACT Nonsense-mutation-containing messenger ribonucleoprotein particles (mRNPs) transit through cytoplasmic foci called P-bodies before undergoing nonsense-mediated mRNA decay (NMD), a cytoplasmic mRNA surveillance mechanism. This study shows that the cytoskeleton modulates transport of nonsense-mutation-containing mRNPs to…
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Keywords:
cytoplasmic foci;
upf proteins;
termination codon;
premature termination ... See more keywords
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Published in 2022 at "BioTechniques"
DOI: 10.2144/btn-2022-0046
Abstract: Cellular protein-protein interactions are largely dependent on the activities of signaling proteins. Here, we present a technique to tune gene expression at translation level based on G418-inducible readthrough premature termination codon (PTC-on). To demonstrate how this PTC-on…
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Keywords:
termination codon;
premature termination;
p53;
approach ... See more keywords
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Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.835164
Abstract: The area between middle and lower reaches of the Yangtze River is the largest region for soft wheat production in China. In soft wheat breeding, the lack of germplasm with desirable quality for end-use products…
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Keywords:
quality;
wheat;
termination codon;
premature termination ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020656
Abstract: Arrhythmogenic cardiomyopathy is a heritable heart disease associated with desmosomal mutations, especially premature termination codon (PTC) variants. It is known that PTC triggers the nonsense-mediated decay (NMD) mechanism. It is also accepted that PTC in…
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Keywords:
premature termination;
region;
termination codon;
reinitiation ... See more keywords