CXCL10 conditions alveolar macrophages within the premetastatic niche to promote metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer letters"
DOI: 10.1016/j.canlet.2022.215667
Abstract: Formation of the premetastatic niche is triggered by primary tumors and contributes to cancer metastasis. Evidence indicating the roles of macrophages in metastatic niche formation and organ-specific metastatic tropism has been steadily accumulating. However, the… read more here.
Keywords: cxcl10; metastasis; ccl12 expression; premetastatic niche ... See more keywords
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add5028
Abstract: Endothelial cells (ECs) grant access of disseminated cancer cells to distant organs. However, the molecular players regulating the activation of quiescent ECs at the premetastatic niche (PMN) remain elusive. Here, we find that ECs at… read more here.
Keywords: trail; endothelial trail; premetastatic niche; cancer cell ... See more keywords
Macrophage-Secreted S100A4 Supports Breast Cancer Metastasis by Remodeling the Extracellular Matrix in the Premetastatic Niche
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/9895504
Abstract: Metastasis is the major cause of cancer-related mortalities. A tumor-supportive microenvironment, also known as the premetastatic niche at secondary tumor sites, plays a crucial role in metastasis. Remodeling of the extracellular matrix (ECM) is essential… read more here.
Keywords: metastasis; breast cancer; premetastatic niche;
Extracellular vesicle-packaged CDH11 and ITGA5 induce the premetastatic niche for bone colonization of breast cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-1331
Abstract: Although most breast cancer metastases in bone cause osteolytic lesions, the osteogenic niche has commonly been described as an initiator of early-stage bone colonization of disseminated cancer cells. Tumor cell-derived extracellular vesicles (EV) have been… read more here.
Keywords: premetastatic niche; cancer cells; niche; breast cancer ... See more keywords
Exosomes from cisplatin-induced dormant cancer cells facilitate the formation of premetastatic niche in bone marrow through activating glycolysis of BMSCs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.922465
Abstract: Introduction Lung cancer is the leading cause of cancer-related deaths worldwide. Chemotherapy kills most cancer cells; however, residual cells enter a dormant state. The dormant cancer cells can be reactivated under specific circumstances. The “premetastatic… read more here.
Keywords: cancer; premetastatic niche; growth; bone marrow ... See more keywords
Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i35.5154
Abstract: BACKGROUND Colorectal cancer (CRC) is a common malignant tumor. Alcohol consumption is positively correlated with CRC malignant metastasis; however, the mechanism is unclear. The interaction between laminin-γ2 (LAMC2) and integrin-β1 (ITGB1) plays a role in… read more here.
Keywords: metastasis; interaction; premetastatic niche; alcohol ... See more keywords