Adverse effects of prenatal dexamethasone exposure on fetal development
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Reproductive Immunology"
DOI: 10.1016/j.jri.2022.103619
Abstract: Dexamethasone has been widely used in clinical practice to promote fetal lung maturity and reduce neonatal respiratory distress syndrome and perinatal mortality. Nevertheless, its administration is a double-edged sword, as a large number of studies… read more here.
Keywords: dexamethasone exposure; fetal development; prenatal dexamethasone; dexamethasone ... See more keywords
Prenatal Dexamethasone Exposure Programs the Development of the Pancreas and the Secretion of Insulin in Rats.
Sign Up to like & getrecommendations! Published in 2017 at "Pediatrics and neonatology"
DOI: 10.1016/j.pedneo.2016.02.008
Abstract: BACKGROUND There is increasing epidemiological evidence indicating that many chronic diseases originate during early life, even before birth, through what are termed fetal programming effects. Prenatal glucocorticoid is frequently used clinically to accelerate the maturation… read more here.
Keywords: secretion insulin; prenatal dexamethasone; dexamethasone; dexamethasone exposure ... See more keywords
Inducible factors and interaction of pulmonary fibrosis induced by prenatal dexamethasone exposure in offspring rats.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2022.02.001
Abstract: This study aimed to investigate the correlation between prenatal dexamethasone exposure (PDE) and susceptibility to pulmonary fibrosis in offspring. Healthy female Wistar rats were given dexamethasone (0.2 mg/kg.d) or an equal volume of normal saline… read more here.
Keywords: female rats; offspring rats; pulmonary fibrosis; treatment ... See more keywords
Rats with prenatal dexamethasone exposure and postnatal high-fat diet exhibited insulin resistance, and spatial learning and memory impairment: effects of enriched environment.
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001406
Abstract: This study aimed to examine the combined effects of prenatal glucocorticoid exposure and a postnatal high-fat diet (HFD) on offspring brain development and metabolic disturbance. Besides, the effects of an enriched environment were assessed. Pregnant… read more here.
Keywords: insulin resistance; enriched environment; prenatal dexamethasone; dexamethasone ... See more keywords
Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue
Sign Up to like & getrecommendations! Published in 2019 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-019-0963-1
Abstract: BackgroundPrenatal dexamethasone treatment has been shown to enhance the susceptibility of offspring to postnatal high-fat (HF) diet-induced programmed obesity. We investigated the metabolic phenotypes, nutrient-sensing signal and circadian-clock genes in adipose tissue that are programmed… read more here.
Keywords: circadian clock; postnatal diet; dexamethasone postnatal; prenatal dexamethasone ... See more keywords