Combined early life stressors: Prenatal nicotine and maternal deprivation interact to influence affective and drug seeking behavioral phenotypes in rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.07.022
Abstract: Abstract Early life stress (ELS) increases the risk for later cognitive and emotional dysfunction, and has been implicated in the etiology of multiple psychiatric disorders. We hypothesize that combined insults during gestation and infancy, critical… read more here.
Keywords: maternal deprivation; prenatal nicotine; early life; pne ... See more keywords
Augmented autophagy suppresses thymocytes development via Bcl10/p-p65 pathway in prenatal nicotine exposed fetal mice.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111272
Abstract: Tobacco smoke is a common global environmental pollutant. Maternal tobacco smoke/nicotine exposure has long-term toxic effects on immune organs. We previously found that prenatal nicotine exposure (PNE)-induced programmed immune diseases caused by fetal thymic hypoplasia,… read more here.
Keywords: thymocytes development; nicotine; prenatal nicotine; pathway ... See more keywords
Attenuated cholesterol metabolism pathway suppresses regulatory T cell development in prenatal nicotine exposed female mice.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.152309
Abstract: The recession of regulatory T cells (Tregs) contributes to development of autoimmune disease. Our previous study suggested that prenatal nicotine exposure (PNE) inhibited Tregs frequency in offspring, but the mechanisms are still uncertain. This study… read more here.
Keywords: prenatal nicotine; cholesterol; pathway; mice ... See more keywords
Effects of prenatal nicotine exposure on hepatic glucose and lipid metabolism in offspring rats and its hereditability.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152378
Abstract: Prenatal nicotine exposure (PNE) could induce an increased susceptibility to multiple chronic diseases in adult offspring, that mainly caused by intrauterine maternal glucocorticoid (GC) over-exposure. We investigated the changes and inheritability of hepatic glucose and… read more here.
Keywords: prenatal nicotine; exposure; hepatic glucose; lipid metabolism ... See more keywords
Prenatal nicotine exposure retards osteoclastogenesis and endochondral ossification in fetal long bones in rats.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.07.005
Abstract: This study investigated the mechanisms underlying the retarded development of long bone in fetus by prenatal nicotine exposure (PNE) which had been demonstrated by our previous work. Nicotine (2.0 mg/kg.d) or saline was injected subcutaneously into… read more here.
Keywords: nicotine exposure; prenatal nicotine; endochondral ossification; ossification ... See more keywords
Prenatal nicotine exposure induces thymic hypoplasia in mice offspring from neonatal to adulthood.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.12.015
Abstract: Clinical study showed that smoking during pregnancy deceased the thymus size in newborns. However, the long-term effect remains unclear. This study was aimed to observe the effects of prenatal nicotine exposure (PNE) on the development… read more here.
Keywords: thymic hypoplasia; nicotine exposure; offspring neonatal; neonatal adulthood ... See more keywords
Attenuated Tregs increase susceptibility to type 1 diabetes in prenatal nicotine exposed female offspring mice.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.08.016
Abstract: The recession of regulatory T cells (Tregs) is pivotal for type 1 diabetes (T1D) progressing. Our previous study observed the decreased Tregs in prenatal nicotine exposure (PNE) offspring, but whether this led to the onset… read more here.
Keywords: pne; female offspring; type diabetes; prenatal nicotine ... See more keywords
Prenatal nicotine exposure affects cardiovascular function and growth of the developing fetus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.14294
Abstract: Effects of nicotine on fetal hemodynamics are not well known, especially in the first trimester fetus. We investigated the acute and chronic effects of nicotine on hemodynamics in pregnant mice and their fetuses using ultrasound.… read more here.
Keywords: nicotine exposure; prenatal nicotine; affects cardiovascular; exposure affects ... See more keywords