Deletion of Androgen Receptor in LepRb Cells Improves Estrous Cycles in Prenatally Androgenized Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad015
Abstract: Androgens are steroid hormones crucial for sexual differentiation of the brain and reproductive function. In excess, however, androgens may decrease fertility as observed in polycystic ovary syndrome, a common endocrine disorder characterized by oligo/anovulation and/or… read more here.
Keywords: estrous cycles; receptor leprb; prenatally androgenized; leprb cells ... See more keywords
Prenatal kisspeptin antagonist exposure prevents polycystic ovary syndrome development in prenatally-androgenized rats in adulthood: An experimental study
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DOI: 10.18502/ijrm.v21i2.12801
Abstract: Abstract Background Increased levels of kisspeptin are associated with hypothalamus-pituitary-ovary axis dysfunction. It may lead to the development of polycystic ovary syndrome (PCOS). Objective We aimed to investigate the effect of prenatal kisspeptin antagonist exposure… read more here.
Keywords: exposed rats; development; kisspeptin antagonist; prenatally androgenized ... See more keywords
Oxidative stress and biochemical markers in prenatally androgenized sheep after neonatal treatment with GnRH agonist
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s190260
Abstract: Background Disruption of the balance between the production of ROS and their removal through enzymatic and non-enzymatic (antioxidant) processes has been proposed as a new mechanism in the pathology of polycystic ovary syndrome (PCOS). Evidence… read more here.
Keywords: prenatally androgenized; gnrh agonist; treatment; neonatal treatment ... See more keywords