O-prenylated 3-carboxycoumarins as a novel class of 15-LOX-1 inhibitors
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DOI: 10.1371/journal.pone.0171789
Abstract: Allyloxy, Isopentenyloxy, geranyloxy and farnesyloxy derivatives of 3-carboxycoumarin, at position 5, 6, 7, and 8, were synthesized and their inhibitory potency against human 15-lipoxygenase-1 (human 15-LOX-1) were determined. Among the synthetic coumarins, O-allyl and O-isopentenyl… read more here.
Keywords: lox; class lox; novel class; prenylated carboxycoumarins ... See more keywords