Prenylation of viral proteins by enzymes of the host: Virus‐driven rationale for therapy with statins and FT/GGT1 inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700014
Abstract: Intracellular bacteria were recently shown to employ eukaryotic prenylation system for modifying activity and ensuring proper intracellular localization of their own proteins. Following the same logic, the proteins of viruses may also serve as prenylation… read more here.
Keywords: proteins enzymes; virus; prenylation viral; enzymes host ... See more keywords
Regioselective Biocatalytic C4‐Prenylation of Unprotected Tryptophan Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200311
Abstract: Regioselective carbon−carbon bond formation belongs to the challenging tasks in organic synthesis. In this context, C−C bond formation catalyzed by 4‐dimethylallyltryptophan synthases (4‐DMATSs) represents a possible tool to regioselectively synthesize C4‐prenylated indole derivatives without site‐specific… read more here.
Keywords: prenylation unprotected; tryptophan derivatives; prenylation; unprotected tryptophan ... See more keywords
Effects of quercetin and artemetin prenylation on bioavailability and bioactivity.
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2021.105137
Abstract: Flavonoids are a huge class of polyphenolic compounds ubiquitous in higher plants, in most food and beverages of natural origin. They could be considered as dietary phenols, which exert many health-promoting effects on human and… read more here.
Keywords: quercetin artemetin; bioavailability; effects quercetin; artemetin prenylation ... See more keywords
Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.020
Abstract: Compartmentalized signaling is critical for cellular organization and specificity of functional outcomes in neurons. Here, we report that post-translational lipidation of newly synthesized proteins in axonal compartments allows for short-term and autonomous responses to extrinsic… read more here.
Keywords: axonally translated; translated rac1; prenylation; prenylation axonally ... See more keywords
Modulation of the prenylation step in Anethum graveolens cultured calli. Part II. The role of p-cumaric acid and boropinic acid
Sign Up to like & getrecommendations! Published in 2018 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2018.07.085
Abstract: Abstract Cultured calli from Anethum graveolens L. have been previously shown to biosynthetically manipulate selected precursors having a phenylpropanoid core leading to an increase or a decrease in their prenylation. In this article, an extension… read more here.
Keywords: boropinic acid; cultured calli; anethum graveolens; acid boropinic ... See more keywords
Combining Isoprenoid Probes with Antibody Markers for Mass Cytometric Analysis of Prenylation in Single Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01509
Abstract: Protein prenylation is an essential post-translational modification that plays a key role in facilitating protein localization. Aberrations in protein prenylation have been indicated in multiple disease pathologies including progeria, some forms of cancer, and Alzheimer's… read more here.
Keywords: cell; combining isoprenoid; prenylation; single cell ... See more keywords
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00886
Abstract: Post-translational prenylation of the small GTP-binding proteins (GTPases) is vital to a plethora of biological processes, including cellular proliferation. We have identified a new class of thienopyrimidine-based bisphosphonate (ThP-BP) inhibitors of the human geranylgeranyl pyrophosphate… read more here.
Keywords: multiple myeloma; geranylgeranyl pyrophosphate; prenylation; pyrophosphate synthase ... See more keywords
Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00374
Abstract: Mutationally activated Ras is one of the most common oncogenic drivers found across all malignancies, and its selective inhibition has long been a goal in both pharma and academia. One of the oldest and most… read more here.
Keywords: mediated delivery; alternative prenylation; covalent inhibitor; farnesyltransferase mediated ... See more keywords
Biosynthesis of the bis-prenylated alkaloids muscoride A and B.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00620
Abstract: Prenylation is a common step in the biosynthesis of many natural products and plays an important role in increasing their structural diversity and enhancing biological activity. Muscoride A is a linear peptide alkaloid that contain… read more here.
Keywords: bis prenylated; alkaloids muscoride; bis; prenylated alkaloids ... See more keywords
Reconstitution of a Reversible Membrane Switch via Prenylation by One-Pot Cell-Free Expression
Sign Up to like & getrecommendations! Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00406
Abstract: Reversible membrane targeting of proteins is one of the key regulators of cellular interaction networks, for example, for signaling and polarization. So-called “membrane switches” are thus highly attractive targets for the design of minimal cells… read more here.
Keywords: membrane switch; cell free; prenylation; membrane ... See more keywords
Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02754-2
Abstract: Respiratory syncytial virus (RSV) is a leading cause of severe respiratory tract infections in children. To uncover new antiviral therapies, we developed a live cell-based high content screening approach for rapid identification of RSV inhibitors… read more here.
Keywords: respiratory syncytial; syncytial virus; infection; virus ... See more keywords