Structure, catalysis, and inhibition mechanism of prenyltransferase
Sign Up to like & getrecommendations! Published in 2020 at "Iubmb Life"
DOI: 10.1002/iub.2418
Abstract: Isoprenoids, also known as terpenes or terpenoids, represent a large family of natural products composed of five‐carbon isopentenyl diphosphate or its isomer dimethylallyl diphosphate as the building blocks. Isoprenoids are structurally and functionally diverse and… read more here.
Keywords: head; structure catalysis; synthase; prenyl synthase ... See more keywords
Combining mutagenesis on Glu281 of prenyltransferase NovQ and metabolic engineering strategies for the increased prenylated activity towards menadione
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10470-w
Abstract: Prenyltransferase NovQ is a vital class involved in the biosynthesis of secondary metabolites such as clorobiocin and novobiocin. To investigate the relationship between structure and catalytic properties of NovQ, here, we have analyzed the substrate-binding… read more here.
Keywords: prenyltransferase novq; menadione; combining mutagenesis; glu281 ... See more keywords
Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.039
Abstract: FamD1 is a novel CloQ/NphB-family indole prenyltransferase which involves in hapalindole-type alkaloid biosynthesis. Here the native FamD1 structure and three protein-ligand complexes are analyzed to investigate the molecular basis of substrate binding and catalysis. FamD1… read more here.
Keywords: hapalindole type; indole prenyltransferase; type alkaloid; alkaloid biosynthesis ... See more keywords
Catalysts for the Enzymatic Lipidation of Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00108
Abstract: ConspectusBiologically active peptides are a major growing class of drugs, but their therapeutic potential is constrained by several limitations including bioavailability and poor pharmacokinetics. The attachment of functional groups like lipids has proven to be… read more here.
Keywords: prenyltransferase; carbon; enzymatic lipidation; lipidation peptides ... See more keywords
Transient Prenyltransferase-Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00509
Abstract: Fusicoccadiene synthase from the fungus Phomopsis amygdali (PaFS) is an assembly-line terpene synthase that catalyzes the first two steps in the biosynthesis of Fusiccocin A, a diterpene glycoside. The C-terminal prenyltransferase domain of PaFS catalyzes… read more here.
Keywords: prenyltransferase; prenyltransferase cyclase; cyclase; fusicoccadiene synthase ... See more keywords
A Fungal Promiscuous UbiA Prenyltransferase Expands the Structural Diversity of Chrodrimanin-Type Meroterpenoids.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00495
Abstract: Prenyltransferases play important roles in the diversification of natural products and the improvement of biological activities. A UbiA-type prenyltransferase CdnC with substrate promiscuity was identified as the pivotal builder of the noncanonical chrodrimanin skeletons, which… read more here.
Keywords: prenyltransferase; prenyltransferase expands; promiscuous ubia; chrodrimanin ... See more keywords
Structure and Specificity of a Permissive Bacterial C-Prenyltransferase
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DOI: 10.1038/nchembio.2285
Abstract: This study highlights the biochemical and structural characterization of the L-tryptophan C-6 C-prenyltransferase PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including… read more here.
Keywords: structure specificity; permissive bacterial; bacterial prenyltransferase; biology ... See more keywords
Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.72
Abstract: Aromatic prenylated metabolites have important biological roles and activities in all living organisms. Compared to their importance in all domains of life, we know relatively little about their substrate scopes and metabolic functions. Here, we… read more here.
Keywords: new prenyltransferase; prenyltransferase; prenyltransferase ubi; identification new ... See more keywords