Gene and MicroRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated With Preoperative Chemoradiotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25441
Abstract: Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, tumor response to pCRT is not uniform, and there are no effective predictive methods. This study investigated whether… read more here.
Keywords: response; preoperative chemoradiotherapy; expression; tumor response ... See more keywords
Development of a novel apoptosis-based tumor regression grade to assess the efficacy of preoperative chemoradiotherapy for rectal cancer: a retrospective single-center study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-021-01948-2
Abstract: Preoperative chemoradiotherapy is used preferably for locally advanced rectal cancer, followed by a watch-and-wait strategy for cases showing clinical complete response. However, there is a discordance between pathological and clinical complete response rates. We aimed… read more here.
Keywords: rectal cancer; apoptosis; preoperative chemoradiotherapy; chemoradiotherapy ... See more keywords
Extramural perineural invasion in pT3 and pT4 rectal adenocarcinoma as prognostic factor after preoperative chemoradiotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2017.03.027
Abstract: Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated in the head and neck and prostate carcinomas, but its significance in rectal cancer is controversial. Most studies have… read more here.
Keywords: perineural invasion; invasion; preoperative chemoradiotherapy; pni ... See more keywords
Systematic review and meta-analysis of preoperative chemoradiotherapy with or without oxaliplatin in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006487
Abstract: Background: Preoperative chemoradiotherapy has become the current standard regimen for locally advanced rectal cancer (LARC). However, the additional benefit of oxaliplatin to preoperative chemotherapy was still controversial. On one hand, oxaliplatin may improve the tumor… read more here.
Keywords: preoperative chemoradiotherapy; chemoradiotherapy; rate; oxaliplatin ... See more keywords
Comment on: Anastomotic Leak Does Not Impact Oncologic Outcomes After Preoperative Chemoradiotherapy and Resection for Rectal Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000003830
Abstract: To the Editor: We have read the interesting article by Jang et al based on a retrospective study from a single high-volume center with experienced colorectal surgeons. The study aims to evaluate the relationship between… read more here.
Keywords: preoperative chemoradiotherapy; oncologic outcomes; rectal cancer; cancer ... See more keywords
Ongoing evolution of preoperative chemoradiotherapy for rectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "ANZ Journal of Surgery"
DOI: 10.1111/ans.14223
Abstract: Colorectal cancer was the third-most commonly diagnosed malignancy in Australia in 2013. It is estimated to become the secondmost common cancer in 2017 with an expected increase with age for both males and females. The… read more here.
Keywords: rectal cancer; response; preoperative chemoradiotherapy; chemoradiotherapy ... See more keywords
UGT1A1 polymorphisms in rectal cancer associated with the efficacy and toxicity of preoperative chemoradiotherapy using irinotecan
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13807
Abstract: The purpose of the present study was to assess the efficacy and toxicity of preoperative chemoradiotherapy using irinotecan against locally advanced lower rectal cancer according to UDP‐glucuronosyltransferase 1A1 (UGT1A1) polymorphisms. Between 2009 and 2016, 46… read more here.
Keywords: rectal cancer; preoperative chemoradiotherapy; chemoradiotherapy; ugt1a1 polymorphisms ... See more keywords
Preoperative Chemoradiotherapy plus Nivolumab before Surgery in Patients with Microsatellite Stable and Microsatellite Instability–High Locally Advanced Rectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-3213
Abstract: Abstract Purpose: Preoperative chemoradiotherapy (CRT) and surgical resection are the standard treatment for locally advanced rectal cancer (LARC). Combining immune checkpoint inhibitors with radiation suggests a promising approach for enhancing efficacy. We investigated the efficacy… read more here.
Keywords: locally advanced; preoperative chemoradiotherapy; surgery; crt ... See more keywords
Preoperative chemoradiotherapy and postoperative chemotherapy with capecitabine +/- oxaliplatin in locally advanced rectal cancer: Final results of PETACC-6.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3500
Abstract: 3500Background: The PETACC-6 trial investigated the role of oxaliplatin in combination with preoperative capecitabine-based chemoradiation (CRT) and postoperative capecitabine (CT) to improve disea... read more here.
Keywords: postoperative chemotherapy; chemoradiotherapy postoperative; preoperative chemoradiotherapy; capecitabine ... See more keywords
Toxicity, Disease Control, and Survival Outcomes of Intensified Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Single-Institution Study
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Management and Research"
DOI: 10.2147/cmar.s398592
Abstract: Purpose The standard treatment regimen of preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC) is still controversial. The purpose of this study was to analyze the efficacy and safety of preoperative intensive CRT in… read more here.
Keywords: cancer; preoperative chemoradiotherapy; control; crt ... See more keywords
Late Recurrence in a Rectal Cancer Patient Who Underwent Preoperative Chemoradiotherapy Followed by Local Excision: A Case Report
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Coloproctology"
DOI: 10.3393/ac.2020.00073.0010
Abstract: Some patients who have undergone preoperative chemoradiotherapy (CRT) following surgery have been diagnosed with late recurrence more than 5 years after treatment, raising questions about the possible benefit extending surveillance beyond the recommended 5 years.… read more here.
Keywords: late recurrence; rectal cancer; recurrence; preoperative chemoradiotherapy ... See more keywords