Biocatalysis: A smart and green tool for the preparation of chiral drugs
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DOI: 10.1002/chir.23498
Abstract: Abstract Over the last decades, biocatalysis has achieved growing interest thanks to its potential to enable high efficiency, high yield, and eco‐friendly processes aimed at the production of pharmacologically relevant compounds. Particularly, biocatalysis proved an… read more here.
Keywords: biocatalysis smart; preparation chiral; chiral drugs; tool preparation ... See more keywords
Exploiting isohexide scaffolds for the preparation of chiral ionic liquids tweezers
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DOI: 10.1016/j.molliq.2020.114528
Abstract: Abstract New bis-quinolinium chiral ionic liquids (CILs) were synthesized in good yields starting from isomannide and isosorbide by a straightforward procedure that maintains the absolute stereostructure of the isohexide scaffolds. Thermal gravimetric analysis and differential… read more here.
Keywords: chiral ionic; scaffolds preparation; exploiting isohexide; ionic liquids ... See more keywords
Preparation of Chiral Enantioenriched Densely Substituted Cyclopropyl Azoles, Amines, and Ethers via Formal SN2′ Substitution of Bromocylopropanes
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DOI: 10.3390/molecules27207069
Abstract: Enantiomerically enriched cyclopropyl ethers, amines, and cyclopropylazole derivatives possessing three stereogenic carbon atoms in a small cycle are obtained via the diastereoselective, formal nucleophilic substitution of chiral, non-racemic bromocyclopropanes. The key feature of this methodology… read more here.
Keywords: substitution; chiral enantioenriched; densely substituted; preparation chiral ... See more keywords