Biocatalysis: A smart and green tool for the preparation of chiral drugs
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23498
Abstract: Abstract Over the last decades, biocatalysis has achieved growing interest thanks to its potential to enable high efficiency, high yield, and eco‐friendly processes aimed at the production of pharmacologically relevant compounds. Particularly, biocatalysis proved an… read more here.
Keywords: biocatalysis smart; preparation chiral; chiral drugs; tool preparation ... See more keywords
4‐Methyltetrahydropyran: a Versatile Alternative Solvent for the Preparation of Chiral BINOL Catalysts and the Asymmetric Alkylation of Aldehydes
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400313
Abstract: We herein report that the highly hydrophobic ether 4‐MeTHP constitutes a promising resource for the development of sustainable synthetic methodologies grounded on the use of organometallic reagents. The beneficial effects of 4‐MeTHP as reaction media are illustrated in the… read more here.
Keywords: versatile alternative; preparation chiral; methyltetrahydropyran versatile; catalysts asymmetric ... See more keywords
Exploiting isohexide scaffolds for the preparation of chiral ionic liquids tweezers
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.114528
Abstract: Abstract New bis-quinolinium chiral ionic liquids (CILs) were synthesized in good yields starting from isomannide and isosorbide by a straightforward procedure that maintains the absolute stereostructure of the isohexide scaffolds. Thermal gravimetric analysis and differential… read more here.
Keywords: chiral ionic; scaffolds preparation; exploiting isohexide; ionic liquids ... See more keywords
Preparation of Chiral α-Aryl Ketones and Aldehydes via Ni-Catalyzed Asymmetric Cross-Electrophile Coupling
Sign Up to like & getrecommendations! Published in 2025 at "Synlett"
DOI: 10.1055/a-2726-4625
Abstract: The preparation of tertiary α-aryl acetals and ketals has been achieved through a Ni-catalyzed reductive cross-coupling approach, utilizing a readily available Ni/Biox catalytic platform. This reaction demonstrates effective enantioselective control over unactivated alkyl radicals adjacent… read more here.
Keywords: ketones aldehydes; preparation chiral; aryl; aryl ketones ... See more keywords
Preparation of Chiral Stationary Phase Based on 1,1'-bi-2-Naphthol for Chiral Enantiomer Separation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmae051
Abstract: Two enantiomeric novel chiral stationary phases (CSPs) R-3-Amide-BINOL CSP (CSP-1) and S-3-Amide-BINOL CSP (CSP-2) were prepared using (R/S)-1,1'-bi-2-naphthol (BINOL) derivatives as chiral selectors. The structure of CSPs was characterized by nuclear magnetic resonance, scanning electron… read more here.
Keywords: csp; separation; chiral stationary; preparation chiral ... See more keywords
Preparation of Chiral Enantioenriched Densely Substituted Cyclopropyl Azoles, Amines, and Ethers via Formal SN2′ Substitution of Bromocylopropanes
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27207069
Abstract: Enantiomerically enriched cyclopropyl ethers, amines, and cyclopropylazole derivatives possessing three stereogenic carbon atoms in a small cycle are obtained via the diastereoselective, formal nucleophilic substitution of chiral, non-racemic bromocyclopropanes. The key feature of this methodology… read more here.
Keywords: substitution; chiral enantioenriched; densely substituted; preparation chiral ... See more keywords