Iridium-Catalyzed Amidation of In Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters.
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DOI: 10.1021/acs.orglett.1c04376
Abstract: Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst.… read more here.
Keywords: catalyzed amidation; silyl ketene; ketene acetals; access ... See more keywords