Preprint Highlight: Pressure and curvature control of contact inhibition in epithelia growing under spherical confinement.
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DOI: 10.1091/mbc.p22-02-1002
Abstract: All living systems evolved molecular mechanisms to respond to their physical surroundings, such as by tuning cell cycle progression as well as transport of different cargo across intracellular compartments. However, it is difficult to determine… read more here.
Keywords: pressure curvature; confinement; cell; highlight pressure ... See more keywords
Preprint Highlight: ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA- dependent STING signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-02-1003
Abstract: Loss-of-function mutations in VPS13C cause familial Parkinson’s disease (PD) and increase the risk to develop the sporadic form of the disease. However, the underlying disease mechanisms remain unclear. It has been previously established that VPS13C… read more here.
Keywords: transfer protein; highlight lysosome; lysosome lipid; vps13c ... See more keywords
Preprint Highlight: Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-02-1005
Abstract: The individual contributions of E- and N-cadherin junctions in collective cell migration, especially in the context of cells transitioning between epithelial and mesenchymal states during cancer progression, are controversial. This study aims to clarify the… read more here.
Keywords: cadherin; cell migration; cancer; cell ... See more keywords
Preprint Highlight: FLAgellum Member 8 modulates extravascular trypanosome distribution in the mammalian host.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-02-1006
Abstract: Trypanosomes are extracellular protozoan parasites that cause human and animal disease. Trypanosomes predominantly inhabit the blood, skin, and adipose tissue and are transmitted by the biting tsetse fly. Little is known of how tissue tropism… read more here.
Keywords: member modulates; flagellum member; highlight flagellum; modulates extravascular ... See more keywords
Preprint Highlight: Growth temperature is the principal driver of chromatinization in archaea.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-02-1007
Abstract: Almost all organisms express proteins that coat and organize DNA (nucleoid-associated proteins or NAPs). NAPs (such as histones in eukaryotes) play many roles, from scaffolding and protecting the DNA to regulating transcription, replication and epigenetic… read more here.
Keywords: growth temperature; temperature principal; growth; highlight growth ... See more keywords
Preprint Highlight: Building the cytokinetic contractile ring in an early embryo: initiation as clusters of myosin II, anillin and septin, and visualization of a septin filament network.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-03-1001
Abstract: Cytokinesis is driven by a contractile ring whose key components are well-defined. Yet how they are organized and how the contractile ring assembles and constricts, remain unclear. This study combines confocal and super resolution imaging… read more here.
Keywords: contractile ring; septin filament; anillin; contractile ... See more keywords
Preprint Highlight: Polarized Disheveled dissolution and condensation drives embryonic axis specification in oocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-03-1002
Abstract: Body axes establishment during animal embryogenesis often relies on the intrinsic asymmetry generated early on in the oocyte by the Wnt/β-catenin pathway. However, it's still unclear how the initial asymmetry arises. Here imaging experiments show… read more here.
Keywords: preprint highlight; dissolution; dissolution condensation; polarized disheveled ... See more keywords
Preprint Highlight: The novel Rab5 effector FERRY links early endosomes with the translation machinery.
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DOI: 10.1091/mbc.p22-04-1001
Abstract: Early endosomes bind certain mRNAs and are thought to facilitate translation thereon, but the mechanism underlying this function is not known. This study identifies a novel Rab 5 effector complex, the five-subunit endosomal Rab5 and… read more here.
Keywords: preprint highlight; highlight novel; novel rab5; early endosomes ... See more keywords
Preprint Highlight: Self-supervised deep learning encodes high-resolution features of protein subcellular localization.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-04-1007
Abstract: The ability to quantitatively characterize protein subcellular spatial organization is key for understanding how cells orchestrate their many functions. This study presents cytoself, a deep‐learning self‐supervised method to compute lower dimensional representations of protein spatial… read more here.
Keywords: highlight self; localization; preprint highlight; protein subcellular ... See more keywords
Preprint Highlight: Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts.
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DOI: 10.1091/mbc.p22-07-1005
Abstract: Despite the importance of osteoclast secretory lysosomes (SLs) in bone digestion and resorption, the proteins that reside on SLs are undercharacterized. The authors show that SLC37a2, a unique member of the SLC37 family of sugar… read more here.
Keywords: preprint highlight; sugar transporter; bone; slc37a2 ... See more keywords
Preprint Highlight: Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-07-1006
Abstract: Cell–cell interactions are involved in cellular decision making, but there is a lack of systematic methods to quantify and interpret their role. This study presents a computational methodology that predicts epidermal cell fate at the… read more here.
Keywords: cell; neural networks; preprint highlight; graph neural ... See more keywords