Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-01003-1
Abstract: Mutations in presenilin 1 and 2 (PS1 and PS2) cause autosomal dominant familial Alzheimer's disease (FAD). Ferroptosis has been implicated as a mechanism of neurodegeneration in AD since neocortical iron burden predicts Alzheimer's disease (AD)… read more here.
Keywords: familial alzheimer; alzheimer disease; ferroptosis; presenilin mutations ... See more keywords
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.313016
Abstract: The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer’s disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is… read more here.
Keywords: alzheimer disease; presenilin mutations; neuronal differentiation; disease ... See more keywords