Abstract 1613: Evolution of mutations in the antigen presentation machinery across cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1613
Abstract: Immune escape is a critical hallmark of cancer progression. Under immunosurveillance, a subset of cancer-associated antigens or neoantigens are presented to the cancer cell surface via the antigen presentation machinery (APM) for recognition by antigen-specific… read more here.
Keywords: evolution; cancer; antigen presentation; history ... See more keywords
Maintenance of Hypoimmunogenic Features via Regulation of Endogenous Antigen Processing and Presentation Machinery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.936584
Abstract: Universally acceptable donor cells have been developed to address the unmet need for immunotypically matched materials for regenerative medicine. Since forced expression of hypoimmunogenic genes represses the immune response, we established universal pluripotent stem cells… read more here.
Keywords: presentation machinery; processing presentation; presentation; hla ... See more keywords