mRNA Delivery System for Targeting Antigen‐Presenting Cells In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800335
Abstract: The encapsulation of mRNA in nanosystems as gene vaccines for immunotherapy purposes has experienced an exponential increase in recent years. Despite the many advantages envisaged within these approaches, their application in clinical treatments is still… read more here.
Keywords: delivery system; presenting cells; mrna delivery; system targeting ... See more keywords
Tissue-specific antigen-presenting cells contribute to distinct phenotypes of allergy.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202249980
Abstract: Antigen presenting cells (APCs) are critical cells bridging innate and adaptive immune responses by taking up, processing, and presenting antigens to naïve T cells. At steady state, APCs thus control both tissue homeostasis and the… read more here.
Keywords: antigen presenting; presenting cells; specific antigen; tissue specific ... See more keywords
Human repair‐related Schwann cells adopt functions of antigen‐presenting cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24257
Abstract: The plastic potential of Schwann cells (SCs) is increasingly recognized to play a role after nerve injury and in diseases of the peripheral nervous system. In addition, reports on the interaction between SCs and immune… read more here.
Keywords: repair related; antigen presenting; schwann cells; presenting cells ... See more keywords
Imaging the Interactions Between B Cells and Antigen-Presenting Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_10
Abstract: In vivo, B cells are often activated by antigens that are displayed on the surface of antigen-presenting cells (APCs). Binding of membrane-associated antigens to the B cell receptor (BCR) causes rapid cytoskeleton-dependent changes in the… read more here.
Keywords: imaging interactions; bcr; presenting cells; model antigens ... See more keywords
Mannosylated Polycations Target CD206+ Antigen-Presenting Cells and Mediate T-Cell-Specific Activation in Cancer Vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00993
Abstract: Immunotherapy is deemed one of the most powerful therapeutic approaches to treat cancer. However, limited response and tumor specificity are still major challenges to address. Herein, mannosylated polycations targeting mannose receptor- are developed as vectors… read more here.
Keywords: cell; antigen presenting; activation; presenting cells ... See more keywords
Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04958k
Abstract: Magnetic poly(l-lactide) coarse microspheres were synthesized via an emulsion method followed by chemical etching. Subsequently, anti-CD3 and anti-CD28 antibodies were attached to the microspheres via an avidin-biotin amplification system as artificial antigen-presenting cells. The activation… read more here.
Keywords: coarse microspheres; antigen presenting; artificial antigen; presenting cells ... See more keywords
Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2016.1256527
Abstract: ABSTRACT While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be… read more here.
Keywords: rna nps; presenting cells; rna; activation ... See more keywords
Targeting of Influenza Viral Epitopes to Antigen-Presenting Cells by Genetically Engineered Chimeric Molecules in a Humanized NOD SCID Gamma Transfer Model.
Sign Up to like & getrecommendations! Published in 2018 at "Human gene therapy"
DOI: 10.1089/hum.2018.100
Abstract: Antiviral DNA vaccines are a novel strategy in the vaccine development field, which basically consists of the administration of expression vectors coding viral antigen sequences into the host's cells. Targeting of conserved viral epitopes by… read more here.
Keywords: presenting cells; humanized nod; viral epitopes; scid gamma ... See more keywords
Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-041015-055700
Abstract: The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as… read more here.
Keywords: extracellular vesicles; presenting cells; professional antigen; antigen ... See more keywords
Factor VIII Trafficking to CD4+ T cells Shapes its Immunogenicity and Requires Several Types of Antigen Presenting Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022018937
Abstract: Despite over 80 years of clinical experience with coagulation factor (F)VIII inhibitors, surprisingly little is known about the in vivo mechanism of this most serious complication of replacement therapy for hemophilia A. These neutralizing anti-drug… read more here.
Keywords: fviii; cd4 cells; antigen presenting; presenting cells ... See more keywords
The differences in immunoadjuvant mechanisms of TLR3 and TLR4 agonists on the level of antigen-presenting cells during immunization with recombinant adenovirus vector
Sign Up to like & getrecommendations! Published in 2018 at "BMC Immunology"
DOI: 10.1186/s12865-018-0264-x
Abstract: BackgroundAgonists of TLR3 and TLR4 are effective immunoadjuvants for different types of vaccines. The mechanisms of their immunostimulatory action differ significantly; these differences are particularly critical for immunization with non-replicating adenovirus vectors (rAds) based vaccines.… read more here.
Keywords: presenting cells; tlr3 tlr4; agonists level; tlr4 agonists ... See more keywords