mRNA Delivery System for Targeting Antigen‐Presenting Cells In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800335
Abstract: The encapsulation of mRNA in nanosystems as gene vaccines for immunotherapy purposes has experienced an exponential increase in recent years. Despite the many advantages envisaged within these approaches, their application in clinical treatments is still… read more here.
Keywords: delivery system; presenting cells; mrna delivery; system targeting ... See more keywords
Surface‐Functionalized Microgels as Artificial Antigen‐Presenting Cells to Regulate Expansion of T Cells
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202309860
Abstract: Artificial antigen‐presenting cells (aAPCs) are currently used to manufacture T cells for adoptive therapy in cancer treatment, but a readily tunable and modular system can enable both rapid T cell expansion and control over T… read more here.
Keywords: antigen; presenting cells; surface; expansion ... See more keywords
Tissue-specific antigen-presenting cells contribute to distinct phenotypes of allergy.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202249980
Abstract: Antigen presenting cells (APCs) are critical cells bridging innate and adaptive immune responses by taking up, processing, and presenting antigens to naïve T cells. At steady state, APCs thus control both tissue homeostasis and the… read more here.
Keywords: antigen presenting; presenting cells; specific antigen; tissue specific ... See more keywords
Human repair‐related Schwann cells adopt functions of antigen‐presenting cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24257
Abstract: The plastic potential of Schwann cells (SCs) is increasingly recognized to play a role after nerve injury and in diseases of the peripheral nervous system. In addition, reports on the interaction between SCs and immune… read more here.
Keywords: repair related; antigen presenting; schwann cells; presenting cells ... See more keywords
Imaging the Interactions Between B Cells and Antigen-Presenting Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_10
Abstract: In vivo, B cells are often activated by antigens that are displayed on the surface of antigen-presenting cells (APCs). Binding of membrane-associated antigens to the B cell receptor (BCR) causes rapid cytoskeleton-dependent changes in the… read more here.
Keywords: imaging interactions; bcr; presenting cells; model antigens ... See more keywords
Mannosylated Polycations Target CD206+ Antigen-Presenting Cells and Mediate T-Cell-Specific Activation in Cancer Vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00993
Abstract: Immunotherapy is deemed one of the most powerful therapeutic approaches to treat cancer. However, limited response and tumor specificity are still major challenges to address. Herein, mannosylated polycations targeting mannose receptor- are developed as vectors… read more here.
Keywords: cell; antigen presenting; activation; presenting cells ... See more keywords
PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-08982-4
Abstract: The gastrointestinal tract is continuously exposed to foreign antigens in food and commensal microorganisms with potential to induce adaptive immune responses. Peripherally induced T regulatory (pTreg) cells are essential for mitigating inflammatory responses to these… read more here.
Keywords: food; tolerance; presenting cells; antigen presenting ... See more keywords
Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-25817-4
Abstract: Major histocompatibility class II (MHC II) is critical for adaptive immunity. MHC II intracellular trafficking and degradation is regulated by ubiquitination. Poly-ubiquitination (Ub) of MHC II directs it away from the plasma membrane and is… read more here.
Keywords: presenting cells; murine; mhc; antigen presenting ... See more keywords
Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04958k
Abstract: Magnetic poly(l-lactide) coarse microspheres were synthesized via an emulsion method followed by chemical etching. Subsequently, anti-CD3 and anti-CD28 antibodies were attached to the microspheres via an avidin-biotin amplification system as artificial antigen-presenting cells. The activation… read more here.
Keywords: coarse microspheres; antigen presenting; artificial antigen; presenting cells ... See more keywords
Self-adjuvanted L-arginine-modified dextran-based nanogels for sustained local antigenic protein delivery to antigen-presenting cells and enhanced cellular and humoral immune responses.
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials science"
DOI: 10.1039/d3bm01150j
Abstract: In the development of cancer vaccines, antigens are delivered to elicit potent and specific T-cell responses to eradicate tumour cells. Nonetheless, successful vaccines are often hampered by the poor immunogenicity of tumour antigens, rapid clearance… read more here.
Keywords: antigen; based nanogels; presenting cells; cellular humoral ... See more keywords
Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2016.1256527
Abstract: ABSTRACT While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be… read more here.
Keywords: rna nps; presenting cells; rna; activation ... See more keywords