Cardiotonic steroids induce vascular fibrosis via pressure-independent mechanism in NaCl-loaded diabetic rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000000730
Abstract: Endogenous cardiotonic steroid, marinobufagenin (MBG), induces Fli1-dependent tissue fibrosis. We hypothesized that an increase in MBG initiates the development of aortic fibrosis in salt-loaded rats with type 2 diabetes mellitus (DM2) via pressure-independent mechanism.DM2 was… read more here.
Keywords: pressure independent; via pressure; mbg; fibrosis ... See more keywords
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15955
Abstract: Small interfering RNA (siRNA) targeting liver angiotensinogen lowers blood pressure, but its effects in hypertensive diabetes are unknown. read more here.
Keywords: pressure independent; blood pressure; liver angiotensinogen; targeting liver ... See more keywords