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Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-07100-y
Abstract: Cardiac dysfunction can occur as a sequela of a state of prolonged pressure overload and postischemic injury. Flavonoids such as quercetin may be protective against cardiovascular disease. This study aimed to systematically assess the effects…
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Keywords:
injury;
cardiac function;
pressure overload;
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Published in 2021 at "Experimental Mechanics"
DOI: 10.1007/s11340-020-00643-z
Abstract: Background The mechanical stimulus (i.e., stress or stretch) for growth occurring in the pressure-overloaded left ventricle (LV) is not exactly known. Objective To address this issue, we investigate the correlation between local ventricular growth (indexed…
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Keywords:
mechanical stimuli;
pressure overload;
correlation;
ventricular growth ... See more keywords
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Published in 2022 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2022.109217
Abstract: BACKGROUND To investigate the mechanisms of potential cardioprotective effects of epigallocatechin-3-gallate (EGCG) in pressure overload-induced cardiac dysfunction. METHODS A chronic heart failure model was established using abdominal aortic constriction (AAC) surgery, rats were divided into…
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Keywords:
pressure overload;
dysfunction;
overload induced;
metabolism ... See more keywords
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Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.11.008
Abstract: Graphical abstract Figure. No Caption available. Abstract As a major amino acid, glycine has multiple functions in metabolism, growth, immunity, cytoprotection, and survival. The aim of this study was to determine the effects of glycine…
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Keywords:
cardiac hypertrophy;
pressure overload;
glycine receptor;
overload induced ... See more keywords
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Published in 2020 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2020.04.011
Abstract: BACKGROUND Combined angiotensin receptor/neprilysin inhibition with sacubitril/valsartan has emerged as a therapy for heart failure (HF). The presumed mechanism of benefit is through prevention of natriuretic peptide (NP) degradation, leading to increased cGMP-dependent protein kinase…
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Keywords:
mice;
pressure overload;
sacubitril valsartan;
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Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.034
Abstract: &NA; Increased oxidative stress and myocyte autophagy co‐exist in cardiac remodeling. However, it is unclear whether oxidative stress mediates maladaptive myocyte autophagy in pathological ventricular remodeling. In this study, we tested the hypothesis that antioxidants…
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Keywords:
myocyte autophagy;
maladaptive myocyte;
pressure overload;
myocyte ... See more keywords
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Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.187
Abstract: L-type Ca2+ channels (LTCC) are known to be involved in the dysregulation of intracellular Ca2+ handling in heart failure (HF) contributing to contractile dysfunction and arrhythmias. Beside alteration in subcellular localization, reduced LTCC function may…
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Keywords:
function;
ca2;
pressure overload;
pka ... See more keywords
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Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03352
Abstract: This study was designed to evaluate the effects of DS37001789, a novel and highly potent urotensin II (U-II) receptor (GPR14) antagonist, against mortality, hypertrophy, and cardiac dysfunction in pressure-overload hypertrophy by transverse aortic constriction (TAC)…
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Keywords:
ds37001789;
pressure overload;
heart failure;
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Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108046
Abstract: Activation of the NLRP3 inflammasome promotes pathological cardiac remodeling induced by pressure overload. However, the therapeutic effects of NLRP3 inhibition after cardiac remodeling remain unknown. The present study aimed to investigate whether the selective NLRP3…
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Keywords:
cardiac remodeling;
mcc950;
pressure overload;
tac ... See more keywords
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Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.162
Abstract: Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart. We recently reported that ALK4 is upregulated in pressure-overloaded heart and ALK4 haplodeficiency attenuated the…
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Keywords:
pressure overload;
like kinase;
receptor like;
activin receptor ... See more keywords
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Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101100
Abstract: Increasing evidence indicates that mitochondrial-associated redox signaling contributes to the pathophysiology of heart failure (HF). The mitochondrial-targeted antioxidant, mitoquinone (MitoQ), is capable of modifying mitochondrial signaling and has shown beneficial effects on HF-dependent mitochondrial dysfunction.…
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Keywords:
mitoq;
dysfunction;
fibrosis;
pressure overload ... See more keywords