Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics investigation
Sign Up to like & getrecommendations! Published in 2024 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-024-01041-5
Abstract: Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of… read more here.
Keywords: pressure; hypertrophy; pressure overload; right ventricular ... See more keywords
Pericardial adipose tissue promotes transition to heart failure with reduced ejection fraction upon pressure-overload in mice
Sign Up to like & getrecommendations! Published in 2025 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-025-01116-x
Abstract: In patients, severity of pressure-induced heart failure (HF) due to aortic stenosis and metabolic disorder correlates with thickness and mass of epicardial adipose tissue (EAT). We examined the role of the less studied pericardial adipose… read more here.
Keywords: pressure; adipose tissue; pressure overload; heart failure ... See more keywords
Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-07100-y
Abstract: Cardiac dysfunction can occur as a sequela of a state of prolonged pressure overload and postischemic injury. Flavonoids such as quercetin may be protective against cardiovascular disease. This study aimed to systematically assess the effects… read more here.
Keywords: injury; cardiac function; pressure overload;
Mechanical Stimuli for Left Ventricular Growth During Pressure Overload
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Mechanics"
DOI: 10.1007/s11340-020-00643-z
Abstract: Background The mechanical stimulus (i.e., stress or stretch) for growth occurring in the pressure-overloaded left ventricle (LV) is not exactly known. Objective To address this issue, we investigate the correlation between local ventricular growth (indexed… read more here.
Keywords: mechanical stimuli; pressure overload; correlation; ventricular growth ... See more keywords
Epigallocatechin-3-gallate exerts cardioprotective effects related to energy metabolism in pressure overload-induced cardiac dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2022.109217
Abstract: BACKGROUND To investigate the mechanisms of potential cardioprotective effects of epigallocatechin-3-gallate (EGCG) in pressure overload-induced cardiac dysfunction. METHODS A chronic heart failure model was established using abdominal aortic constriction (AAC) surgery, rats were divided into… read more here.
Keywords: pressure overload; dysfunction; overload induced; metabolism ... See more keywords
Glycine prevents pressure overload induced cardiac hypertrophy mediated by glycine receptor
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.11.008
Abstract: Graphical abstract Figure. No Caption available. Abstract As a major amino acid, glycine has multiple functions in metabolism, growth, immunity, cytoprotection, and survival. The aim of this study was to determine the effects of glycine… read more here.
Keywords: cardiac hypertrophy; pressure overload; glycine receptor; overload induced ... See more keywords
Sacubitril/valsartan improves LV function in chronic pressure overload independently of intact cGMP-dependent protein kinase I alpha signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2020.04.011
Abstract: BACKGROUND Combined angiotensin receptor/neprilysin inhibition with sacubitril/valsartan has emerged as a therapy for heart failure (HF). The presumed mechanism of benefit is through prevention of natriuretic peptide (NP) degradation, leading to increased cGMP-dependent protein kinase… read more here.
Keywords: mice; pressure overload; sacubitril valsartan;
Antioxidant N‐acetylcysteine inhibits maladaptive myocyte autophagy in pressure overload induced cardiac remodeling in rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.034
Abstract: &NA; Increased oxidative stress and myocyte autophagy co‐exist in cardiac remodeling. However, it is unclear whether oxidative stress mediates maladaptive myocyte autophagy in pathological ventricular remodeling. In this study, we tested the hypothesis that antioxidants… read more here.
Keywords: myocyte autophagy; maladaptive myocyte; pressure overload; myocyte ... See more keywords
Modulation of cardiac function by oxidized type I protein kinase A
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.187
Abstract: L-type Ca2+ channels (LTCC) are known to be involved in the dysregulation of intracellular Ca2+ handling in heart failure (HF) contributing to contractile dysfunction and arrhythmias. Beside alteration in subcellular localization, reduced LTCC function may… read more here.
Keywords: function; ca2; pressure overload; pka ... See more keywords
The urotensin II receptor antagonist DS37001789 ameliorates mortality in pressure-overload mice with heart failure
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03352
Abstract: This study was designed to evaluate the effects of DS37001789, a novel and highly potent urotensin II (U-II) receptor (GPR14) antagonist, against mortality, hypertrophy, and cardiac dysfunction in pressure-overload hypertrophy by transverse aortic constriction (TAC)… read more here.
Keywords: ds37001789; pressure overload; heart failure;
Selective Inhibition of NLRP3 Inflammasome Reverses Pressure Overload-Induced Pathological Cardiac Remodeling by Attenuating Hypertrophy, Fibrosis, and Inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108046
Abstract: Activation of the NLRP3 inflammasome promotes pathological cardiac remodeling induced by pressure overload. However, the therapeutic effects of NLRP3 inhibition after cardiac remodeling remain unknown. The present study aimed to investigate whether the selective NLRP3… read more here.
Keywords: cardiac remodeling; mcc950; pressure overload; tac ... See more keywords