Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.118.314438
Abstract: Rationale: The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors, and neurohumoral mediators stimulate fibroblast activation, inducing ECM (extracellular matrix) protein synthesis and promoting… read more here.
Keywords: activation; pressure overloaded; matrix; overloaded myocardium ... See more keywords
Prostacyclins have no direct inotropic effect on isolated atrial strips from the normal and pressure-overloaded human right heart
Sign Up to like & getrecommendations! Published in 2017 at "Pulmonary Circulation"
DOI: 10.1177/2045893217691532
Abstract: Prostacyclins are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostacyclins on right heart function are still not clarified. The aim of this study was to investigate the possible… read more here.
Keywords: pressure overloaded; right heart; human right; direct inotropic ... See more keywords
Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20165520
Abstract: This study investigated the influence of antihypertensive drugs, such as angiotensin-converting enzyme inhibitors (ACEIs), AT1 receptor blockers (ARBs), voltage-gated L-type calcium channel blockers, and mineralocorticoid receptor antagonists (MRAs), on the effects of angiotensin-(1-7) [Ang-(1-7)] on… read more here.
Keywords: pressure overloaded; overloaded rats; effect; influence antihypertensive ... See more keywords
Galectin-3 plasma levels in adult congenital heart disease and the pressure overloaded right ventricle: reason matters.
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DOI: 10.2217/bmm-2020-0250
Abstract: Aim: To assess galectin-3 (Gal-3) levels and their relationship with clinical status and right ventricular (RV) performance in adults with RV pressure overload of various mechanisms due to congenital heart disease. Materials & methods: A… read more here.
Keywords: heart disease; pressure overloaded; congenital heart; pressure ... See more keywords