RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes
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DOI: 10.1016/j.neuron.2018.03.011
Abstract: Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca2+ channels, and the presence of the phospholipid PIP2 in the target membrane. Although the presynaptic active zone mediates… read more here.
Keywords: c2b; presynaptic active; rim c2b; active zone ... See more keywords
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.773209
Abstract: Selective distribution of proteins in presynaptic active zones (AZs) is a prerequisite for generating postsynaptic target cell type-specific differences in presynaptic vesicle release probability (Pv) and short-term plasticity, a characteristic feature of cortical pyramidal cells… read more here.
Keywords: mglur1 expressing; munc13; expressing interneurons; presynaptic active ... See more keywords
Diverse organization of voltage-gated calcium channels at presynaptic active zones
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DOI: 10.3389/fnsyn.2022.1023256
Abstract: Synapses are highly organized but are also highly diverse in their organization and properties to allow for optimizing the computing power of brain circuits. Along these lines, voltage-gated calcium (CaV) channels at the presynaptic active… read more here.
Keywords: diverse organization; calcium; voltage gated; presynaptic active ... See more keywords
Visualizing Presynaptic Active Zones and Synaptic Vesicles
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DOI: 10.3389/fnsyn.2022.901341
Abstract: The presynaptic active zone (AZ) of chemical synapses is a highly dynamic compartment where synaptic vesicle fusion and neurotransmitter release take place. During evolution the AZ was optimized for speed, accuracy, and reliability of chemical… read more here.
Keywords: synaptic vesicles; microscopy; presynaptic active; zones synaptic ... See more keywords