The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy
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DOI: 10.1371/journal.pbio.3002030
Abstract: Autophagy is essential for cellular homeostasis and function. In neurons, autophagosome biogenesis is temporally and spatially regulated to occur near presynaptic sites, in part via the trafficking of autophagy transmembrane protein ATG-9. The molecules that… read more here.
Keywords: sorting atg; active zone; presynaptic autophagy; zone ... See more keywords
Presynaptic Autophagy and the Connection With Neurotransmission
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DOI: 10.3389/fcell.2021.790721
Abstract: Autophagy is an evolutionary conserved catabolic pathway essential for the maintenance of cellular homeostasis. Defective proteins and organelles are engulfed by autophagosomal membranes which fuse with lysosomes for cargo degradation. In neurons, the orchestrated progression… read more here.
Keywords: presynaptic autophagy; connection neurotransmission; neurotransmission; autophagy ... See more keywords
Organization of Presynaptic Autophagy-Related Processes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.829354
Abstract: Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand… read more here.
Keywords: presynaptic autophagy; related processes; organization; autophagy related ... See more keywords