Active zone compaction correlates with presynaptic homeostatic potentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109770
Abstract: Neurotransmitter release is stabilized by homeostatic plasticity. Presynaptic homeostatic potentiation (PHP) operates on timescales ranging from minute- to life-long adaptations and likely involves reorganization of presynaptic active zones (AZs). At Drosophila melanogaster neuromuscular junctions, earlier… read more here.
Keywords: homeostatic potentiation; microscopy; compaction; php ... See more keywords
Presynaptic Homeostatic Plasticity Staves off Neurodegenerative Pathophysiology up to a Tipping Point
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.06.013
Abstract: In this issue of Neuron, Orr et al. (2020) identify an evolutionarily conserved mechanism of presynaptic homeostatic plasticity induced by ALS-like motor neuron degeneration, which maintains excitatory potentials until a threshold of synaptic loss is reached.… read more here.
Keywords: homeostatic plasticity; tipping point; plasticity staves; presynaptic homeostatic ... See more keywords
Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1074304
Abstract: Neurotransmitter release at presynaptic active zones (AZs) requires concerted protein interactions within a dense 3D nano-hemisphere. Among the complex protein mesh-work the (M)unc-13 family member Unc-13 of Drosophila melanogaster is essential for docking of synaptic… read more here.
Keywords: homeostatic potentiation; presynaptic homeostatic; active zones; unc 13gfstf ... See more keywords
Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.40385
Abstract: Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of neurotransmitter release, an effect that can exceed 200%. An unexplained property of PHP is the preservation of short-term… read more here.
Keywords: homeostatic plasticity; molecular mechanisms; short term; plasticity ... See more keywords