Closing the gap: long-term presynaptic plasticity in brain function and disease
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.05.011
Abstract: Synaptic plasticity is critical for experience-dependent adjustments of brain function. While most research has focused on the mechanisms that underlie postsynaptic forms of plasticity, comparatively little is known about how neurotransmitter release is altered in… read more here.
Keywords: long term; presynaptic plasticity; plasticity; brain function ... See more keywords
Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.22567
Abstract: Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how the functions of the multiple domains of Munc13–1 are coordinated. The crystal… read more here.
Keywords: crystal structure; presynaptic plasticity; neurotransmitter release; structure ... See more keywords