It’s lights out for presynaptic terminals
Sign Up to like & getrecommendations! Published in 2021 at "Neuron"
DOI: 10.1016/j.neuron.2021.05.015
Abstract: Reliable optogenetic tools for sustained, projection-specific presynaptic silencing have been elusive. Recently in Neuron, Mahn et al. (2021) and Copits et al. (2021) describe how the light-activated inhibitory GPCRs eOPN3 and PPO can be used to reversibly… read more here.
Keywords: lights presynaptic; presynaptic terminals;
Ceftriaxone regulates glutamate production and vesicular assembly in presynaptic terminals through GLT-1 in APP/PS1 mice
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2021.107480
Abstract: Perturbations in the glutamate-glutamine cycle and glutamate release from presynaptic terminals have been involved in the development of cognitive deficits in Alzheimer's disease (AD) patients and mouse models. Glutamate transporter-1 (GLT-1) removes glutamate from the… read more here.
Keywords: ceftriaxone; app ps1; ps1 mice; presynaptic terminals ... See more keywords
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aau3644
Abstract: Local translation in presynaptic terminals Proteins carry out most of the functions in cells, including neurons, which are one of the most morphologically complex cell types in the body. This poses challenges for how proteins… read more here.
Keywords: presynaptic terminals; microscopy; pre postsynaptic; protein synthesis ... See more keywords