Pretomanid: First Approval
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DOI: 10.1007/s40265-019-01207-9
Abstract: Pretomanid, an oral nitroimidazooxazine antimycobacterial agent administered as part of the BPaL (bedaquiline, pretomanid and linezolid) and BPaMZ (bedaquiline, pretomanid, moxifloxacin and pyrazinamide) regimens, has been developed by the Global Alliance for TB Drug Development… read more here.
Keywords: part; pretomanid; first approval; alliance ... See more keywords
Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824)
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DOI: 10.1038/s41598-018-23110-1
Abstract: Pretomanid is a promising anti-tubercular drug currently at clinical phase III, but its mechanisms of action are currently unclear. This study aimed to: (i) reveal the metabolome of Mycobacterium smegmatis under pretomanid treatment; (ii) compare… read more here.
Keywords: pretomanid; metabolomics reveals; pretomanid treatment; reveals new ... See more keywords
Delamanid or pretomanid? A Solomonic judgement!
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DOI: 10.1093/jac/dkab505
Abstract: Abstract Given the low treatment success rates of drug-resistant tuberculosis (TB), novel TB drugs are urgently needed. The landscape of TB treatment has changed considerably over the last decade with the approval of three new… read more here.
Keywords: pretomanid solomonic; drug; delamanid pretomanid; activity ... See more keywords
Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid
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DOI: 10.1093/jac/dkac070
Abstract: Abstract Objectives To develop a robust phenotypic antimicrobial susceptibility testing (AST) method with a correctly set breakpoint for pretomanid (Pa), the most recently approved anti-tuberculosis drug. Methods The Becton Dickinson Mycobacterial Growth Indicator Tube™ (MGIT)… read more here.
Keywords: mycobacterium tuberculosis; tuberculosis; pretomanid; tuberculosis complex ... See more keywords
Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202208-1475oc
Abstract: RATIONALE Pretomanid is a new nitroimidazole with proven treatment-shortening efficacy in drug-resistant tuberculosis. Pretomanid-rifamycin-pyrazinamide combinations are potent in mice but have not been tested clinically. Rifampicin, but not rifabutin, reduces pretomanid exposures. OBJECTIVE Evaluate the… read more here.
Keywords: containing regimens; arm arm; arm; tuberculosis ... See more keywords
Assessment of the Carcinogenic Potential of Pretomanid in Transgenic Tg.rasH2 Mice
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DOI: 10.1177/10915818221113295
Abstract: Pretomanid is a nitroimidazooxazine antimycobacterial drug that was approved as part of a three-drug oral regimen, consisting of bedaquiline, pretomanid, and linezolid, for 6-months treatment of adults with pulmonary extensively drug-resistant tuberculosis or with complicated… read more here.
Keywords: rash2 mice; pretomanid; potential pretomanid; carcinogenic potential ... See more keywords