Alternative analytic and matching approaches for the prevalent new‐user design: A simulation study
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DOI: 10.1002/pds.5446
Abstract: To describe the creation of prevalent new user (PNU) cohorts and compare the relative bias and computational efficiency of several alternative analytic and matching approaches in PNU studies. read more here.
Keywords: alternative analytic; analytic matching; matching approaches; prevalent new ... See more keywords
Clarifying the causal contrast: An empirical example applying the prevalent new user study design
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DOI: 10.1002/pds.5790
Abstract: The prevalent new user design extends the active comparator new user design to include patients switching to a treatment of interest from a comparator. We examined the impact of adding “switchers” to incident new users… read more here.
Keywords: new user; causal contrast; design; clarifying causal ... See more keywords
Effectiveness of Aspirin on Major COPD Outcomes: A Prevalent New-User Design Observational Study
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DOI: 10.1080/15412555.2024.2317380
Abstract: Abstract Observational studies that have reported an association between aspirin use in chronic obstructive pulmonary disease (COPD) with reductions in mortality and COPD exacerbations were shown to be affected by time-related biases. We assessed this… read more here.
Keywords: exacerbation; copd; aspirin use; mortality ... See more keywords
Initiator Types and the Causal Question of the Prevalent New User Design: A Simulation Study.
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DOI: 10.1093/aje/kwaa283
Abstract: New user designs restricting to treatment initiators have become the preferred design for studying drug comparative safety and effectiveness using non-experimental data. This design reduces confounding by indication and healthy adherer bias at the cost… read more here.
Keywords: treatment; study; user design; prevalent new ... See more keywords
Invited Commentary: The Prevalent New User Design in Pharmacoepidemiology: Challenges and Opportunities.
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DOI: 10.1093/aje/kwaa284
Abstract: The prevalent new user design includes a broader study population than the traditional new user approach that is frequently used in pharmacoepidemiologic research. In an article appearing in this issue (Am J Epidemiol. XXXX;XXX(XX):XXXX-XXXX), Webster-Clark… read more here.
Keywords: user design; invited commentary; prevalent new; new user ... See more keywords
The prevalent new-user design for studies with no active comparator: The example of statins and cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Epidemiology"
DOI: 10.1097/ede.0000000000001628
Abstract: BACKGROUND Observational studies evaluating the effect of a drug versus "non-use" are challenging, mainly when defining cohort entry for non-users. The approach using successive monthly cohorts to emulate the randomized trial can be perceived as… read more here.
Keywords: design; prevalent new; user design; new user ... See more keywords