Contradictory roles of Nrf2/Keap1 signaling pathway in cancer prevention/promotion and chemoresistance.
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DOI: 10.1016/j.dnarep.2017.03.008
Abstract: NF-E2-related factor 2 (Nrf2) protein is a cytosolic transcription factor that regulates antioxidant and stress-related enzymes. Kelch-like ECH-associated protein 1 (Keap1) binds Nrf2 and accelerates ubiquitination and proteasome-dependent degradation of Nrf2. Nrf2 modifies the sensitivity… read more here.
Keywords: cancer; nrf2 keap1; prevention promotion; chemoresistance ... See more keywords