Strengthening stakeholder engagement through ethics review in biomedical HIV prevention trials: opportunities and complexities
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DOI: 10.1002/jia2.25172
Abstract: Clinical trials of biomedical HIV prevention modalities require the cooperation of multiple stakeholders. Key stakeholders, such as community members, may have stark vulnerabilities. Consequently, calls for HIV prevention researchers to implement “stakeholder engagement” are increasingly… read more here.
Keywords: hiv prevention; ethics review; prevention trials; stakeholder engagement ... See more keywords
The potential of solanezumab and gantenerumab to prevent Alzheimer’s disease in people with inherited mutations that cause its early onset
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2018.1389885
Abstract: ABSTRACT Introduction: The recent failure of several clinical trials on anti-β-amyloid (Aβ) drugs in Alzheimer’s disease (AD) suggested earlier intervention in the disease course. Secondary prevention trials have been started in autosomal-dominant AD (ADAD) individuals… read more here.
Keywords: alzheimer disease; solanezumab gantenerumab; disease; prevention trials ... See more keywords
Viral Genetic Linkage Analysis Among Black Men Who Have Sex With Men (HIV Prevention Trials Network 061)
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DOI: 10.1089/aid.2018.0204
Abstract: Abstract Analysis of viral genetic linkage can reveal generalized transmission patterns within a population. The HIV Prevention Trials Network 061 study evaluated HIV incidence among black men who ... read more here.
Keywords: hiv prevention; viral genetic; prevention trials; trials network ... See more keywords
Incidence and Correlates of Sexually Transmitted Infections Among Black Men Who Have Sex With Men Participating in the HIV Prevention Trials Network 073 Preexposure Prophylaxis Study
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DOI: 10.1093/cid/ciy1141
Abstract: The HIV Prevention Trials Network (HPTN) Study 073 (HPTN 073) assessed the feasibility, acceptability, and safety of preexposure prophylaxis (PrEP) for black men who have sex with men (BMSM). The purpose of this analysis was… read more here.
Keywords: hiv; incidence; prevention trials; hiv prevention ... See more keywords
Characteristics Associated With Human Immunodeficiency Virus Transmission Networks Involving Adolescent Girls and Young Women in Human Immunodeficiency Virus Prevention Trials Network 068 Study.
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DOI: 10.1097/olq.0000000000000954
Abstract: We combined behavioral survey data from the human immunodeficiency virus (HIV) Prevention Trials Network 068 study with phylogenetic information to determine if cluster membership was associated with characteristics of young women and their partners. Clusters… read more here.
Keywords: young women; immunodeficiency virus; human immunodeficiency; prevention trials ... See more keywords
Core outcomes for pressure ulcer prevention trials: results of an international consensus study
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DOI: 10.1111/bjd.21741
Abstract: There is substantial heterogeneity between trial outcomes in pressure ulcer prevention research. The development of core outcome sets is one strategy to improve comparability between trial results and thus increase the quality of evidence. read more here.
Keywords: ulcer prevention; prevention trials; pressure ulcer; core outcomes ... See more keywords
Evaluating group-sequential non-inferiority clinical trials following interim stopping: The HIV Prevention Trials Network 083 trial
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DOI: 10.1177/17407745221118371
Abstract: Background/Aims: The HIV Prevention Trials Network 083 trial was a group-sequential non-inferiority trial designed to compare HIV incidence under a novel experimental regimen for HIV prevention, long-acting injectable cabotegravir, with an active-control regimen of daily… read more here.
Keywords: hiv prevention; prevention trials; network 083; trials network ... See more keywords
“Spatial heterogeneity of environmental risk in randomized prevention trials: consequences and modeling”
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DOI: 10.1186/s12874-019-0759-z
Abstract: BackgroundIn the context of environmentally influenced communicable diseases, proximity to environmental sources results in spatial heterogeneity of risk, which is sometimes difficult to measure in the field. Most prevention trials use randomization to achieve comparability… read more here.
Keywords: risk; randomized prevention; heterogeneity; prevention trials ... See more keywords
Barriers to Screening: An Analysis of Factors Impacting Screening for Type 1 Diabetes Prevention Trials
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DOI: 10.1210/jendso/bvad003
Abstract: Abstract Context Participants with stage 1 or 2 type 1 diabetes (T1D) qualify for prevention trials, but factors involved in screening for such trials are largely unknown. Objective To identify factors associated with screening for… read more here.
Keywords: prevention trials; prevention; prevention trial; type diabetes ... See more keywords
What to Test in Parkinson Disease Prevention Trials? Repurposed, Low-Risk, and Gene-Targeted Drugs.
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DOI: 10.1212/wnl.0000000000200238
Abstract: Despite the sound epidemiologic and basic science rationales underpinning numerous "disease modification" trials in manifest Parkinson disease (PD), none has convincingly demonstrated that a treatment slows progression. Rapidly expanding knowledge of the genetic determinants and… read more here.
Keywords: prevention trials; prevention; parkinson disease; risk ... See more keywords
Planning for Prevention of Parkinson Disease
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DOI: 10.1212/wnl.0000000000200789
Abstract: Parkinson disease (PD) is a chronic progressive neurodegenerative disease with increasing worldwide prevalence. Despite many trials of neuroprotective therapies in manifest PD, no disease-modifying therapy has been established. Over the past several decades, a series… read more here.
Keywords: prevention trials; prevention; disease; parkinson disease ... See more keywords