Drop‐offs in the isoniazid preventive therapy cascade among children living with HIV in western Kenya, 2015–2019
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DOI: 10.1002/jia2.25939
Abstract: Isoniazid preventive therapy (IPT) can reduce the risk of tuberculosis (TB) in children living with HIV (CLHIV), but data on the outcomes of the IPT cascade in CLHIV are limited. read more here.
Keywords: living hiv; isoniazid preventive; preventive therapy; children living ... See more keywords
Uptake of breast cancer preventive therapy in the UK: results from a multicentre prospective survey and qualitative interviews
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DOI: 10.1007/s10549-018-4775-1
Abstract: PurposeUptake of preventive therapy for women at increased breast cancer risk in England is unknown following the introduction of UK clinical guidelines in 2013. Preventive therapy could create socioeconomic inequalities in cancer incidence if it… read more here.
Keywords: cancer; preventive therapy; survey; breast cancer ... See more keywords
Beliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study
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DOI: 10.1016/j.clbc.2018.10.008
Abstract: Micro‐Abstract Preventive therapies, such as tamoxifen, are a risk reduction option for women at increased risk of breast cancer. Little is known about the psychological factors influencing the decision to use chemoprevention. Using latent profile… read more here.
Keywords: cancer; risk; preventive therapy; breast cancer ... See more keywords
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis
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DOI: 10.1016/s0140-6736(20)30166-5
Abstract: BACKGROUND Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and… read more here.
Keywords: preventive therapy; risk; tuberculosis; age ... See more keywords
Potential population level impact on tuberculosis incidence of using an mRNA expression signature correlate-of-risk test to target tuberculosis preventive therapy
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DOI: 10.1038/s41598-019-47645-z
Abstract: Achieving the WHO End-Tuberculosis (TB) targets requires approaches to prevent progression to TB among individuals with Mycobacterium tuberculosis (M.tb) infection. Effective preventive therapy (PT) exists, but current tests have low specificity for identifying who, among… read more here.
Keywords: incidence; population level; impact; preventive therapy ... See more keywords
Isoniazid preventive therapy modulates Mycobacterium tuberculosis-specific T-cell responses in individuals with latent tuberculosis and type 2 diabetes
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DOI: 10.1038/s41598-025-95386-z
Abstract: Diabetes mellitus (DM) is a significant contributor to tuberculosis (TB) incidence and poor treatment outcomes. This study explored the impact of isoniazid preventive therapy (IPT) on Mycobacterium tuberculosis (Mtb)-specific T-cell memory phenotypes and function among… read more here.
Keywords: preventive therapy; specific cell; tuberculosis; cell ... See more keywords
Adherence, tolerability, and outcome after 36 months of isoniazid-preventive therapy in 2 rural clinics of Swaziland
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DOI: 10.1097/md.0000000000007740
Abstract: Abstract Although efficacy of 36 months isoniazid preventive therapy (IPT) among HIV-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings. This is a prospective observational… read more here.
Keywords: isoniazid preventive; clinics swaziland; rural clinics; months isoniazid ... See more keywords
Isoniazid preventive therapy-related adverse events among Malawian adults on antiretroviral therapy: A cohort study
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DOI: 10.1097/md.0000000000030591
Abstract: Adverse events may be a cause of observed poor completion of isoniazid preventive therapy (IPT) among people living with HIV in high tuberculosis burden areas. Data on IPT-related adverse events (AE) from sub-Saharan Africa are… read more here.
Keywords: ipt related; isoniazid preventive; preventive therapy; ipt ... See more keywords
Isoniazid preventive therapy and tuberculosis transcriptional signatures in people with HIV
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DOI: 10.1097/qad.0000000000003262
Abstract: Objective(s): To examine the association between isoniazid preventive therapy (IPT) or nontuberculous mycobacteria (NTM) sputum culture positivity and tuberculosis (TB) transcriptional signatures in people with HIV. Design: Cross-sectional study. Methods: We enrolled adults living with… read more here.
Keywords: transcriptional signatures; people hiv; therapy; preventive therapy ... See more keywords
High burden of adverse drug reactions to Isoniazid Preventive Therapy in people living with HIV at three tertiary hospitals in Uganda: associated factors.
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DOI: 10.1097/qai.0000000000002842
Abstract: BACKGROUND HIV is one of the most important risk factors for TB-related morbidity and mortality. Isoniazid preventive therapy (IPT) is recommended to prevent latent TB reactivation in HIV patients. However, due to multiple therapies and… read more here.
Keywords: isoniazid preventive; ipt; drug reactions; preventive therapy ... See more keywords
Adverse drug reactions related to isoniazid preventive therapy among persons living with HIV on dolutegravir-based regimens in Uganda between July 2019 and March 2020.
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DOI: 10.1097/qai.0000000000003802
Abstract: BACKGROUND Isoniazid preventive therapy (IPT) is recommended for the treatment of latent tuberculosis (TB) infection and is beneficial for persons living with HIV (PLHIV) even after initiation of antiretroviral therapy (ART). After the roll out… read more here.
Keywords: preventive therapy; isoniazid preventive; hiv; history ... See more keywords