Drop‐offs in the isoniazid preventive therapy cascade among children living with HIV in western Kenya, 2015–2019
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25939
Abstract: Isoniazid preventive therapy (IPT) can reduce the risk of tuberculosis (TB) in children living with HIV (CLHIV), but data on the outcomes of the IPT cascade in CLHIV are limited. read more here.
Keywords: living hiv; isoniazid preventive; preventive therapy; children living ... See more keywords
Uptake of breast cancer preventive therapy in the UK: results from a multicentre prospective survey and qualitative interviews
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4775-1
Abstract: PurposeUptake of preventive therapy for women at increased breast cancer risk in England is unknown following the introduction of UK clinical guidelines in 2013. Preventive therapy could create socioeconomic inequalities in cancer incidence if it… read more here.
Keywords: cancer; preventive therapy; survey; breast cancer ... See more keywords
Beliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Breast Cancer"
DOI: 10.1016/j.clbc.2018.10.008
Abstract: Micro‐Abstract Preventive therapies, such as tamoxifen, are a risk reduction option for women at increased risk of breast cancer. Little is known about the psychological factors influencing the decision to use chemoprevention. Using latent profile… read more here.
Keywords: cancer; risk; preventive therapy; breast cancer ... See more keywords
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "The Lancet"
DOI: 10.1016/s0140-6736(20)30166-5
Abstract: BACKGROUND Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and… read more here.
Keywords: preventive therapy; risk; tuberculosis; age ... See more keywords
Potential population level impact on tuberculosis incidence of using an mRNA expression signature correlate-of-risk test to target tuberculosis preventive therapy
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47645-z
Abstract: Achieving the WHO End-Tuberculosis (TB) targets requires approaches to prevent progression to TB among individuals with Mycobacterium tuberculosis (M.tb) infection. Effective preventive therapy (PT) exists, but current tests have low specificity for identifying who, among… read more here.
Keywords: incidence; population level; impact; preventive therapy ... See more keywords
Adherence, tolerability, and outcome after 36 months of isoniazid-preventive therapy in 2 rural clinics of Swaziland
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000007740
Abstract: Abstract Although efficacy of 36 months isoniazid preventive therapy (IPT) among HIV-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings. This is a prospective observational… read more here.
Keywords: isoniazid preventive; clinics swaziland; rural clinics; months isoniazid ... See more keywords
Isoniazid preventive therapy-related adverse events among Malawian adults on antiretroviral therapy: A cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030591
Abstract: Adverse events may be a cause of observed poor completion of isoniazid preventive therapy (IPT) among people living with HIV in high tuberculosis burden areas. Data on IPT-related adverse events (AE) from sub-Saharan Africa are… read more here.
Keywords: ipt related; isoniazid preventive; preventive therapy; ipt ... See more keywords
Isoniazid preventive therapy and tuberculosis transcriptional signatures in people with HIV
Sign Up to like & getrecommendations! Published in 2022 at "AIDS"
DOI: 10.1097/qad.0000000000003262
Abstract: Objective(s): To examine the association between isoniazid preventive therapy (IPT) or nontuberculous mycobacteria (NTM) sputum culture positivity and tuberculosis (TB) transcriptional signatures in people with HIV. Design: Cross-sectional study. Methods: We enrolled adults living with… read more here.
Keywords: transcriptional signatures; people hiv; therapy; preventive therapy ... See more keywords
High burden of adverse drug reactions to Isoniazid Preventive Therapy in people living with HIV at three tertiary hospitals in Uganda: associated factors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of acquired immune deficiency syndromes"
DOI: 10.1097/qai.0000000000002842
Abstract: BACKGROUND HIV is one of the most important risk factors for TB-related morbidity and mortality. Isoniazid preventive therapy (IPT) is recommended to prevent latent TB reactivation in HIV patients. However, due to multiple therapies and… read more here.
Keywords: isoniazid preventive; ipt; drug reactions; preventive therapy ... See more keywords
Efficacy of Long-Acting Bedaquiline Regimens in a Mouse Model of Tuberculosis Preventive Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202012-4541oc
Abstract: RATIONALE Completion of preventive therapy is a major bottleneck in global tuberculosis control. Long-acting injectable drug formulations would shorten therapy administration and may thereby improve completion rates. Recently, a long-acting formulation of bedaquiline demonstrated anti-tuberculosis… read more here.
Keywords: preventive therapy; tuberculosis; long acting; acting bedaquiline ... See more keywords
The predicted impact of tuberculosis preventive therapy: the importance of disease progression assumptions
Sign Up to like & getrecommendations! Published in 2020 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-020-05592-5
Abstract: Background Following infection with Mycobacterium tuberculosis ( M.tb ), individuals may rapidly develop tuberculosis (TB) disease or enter a “latent” infection state with a low risk of progression to disease. Mathematical models use a variety… read more here.
Keywords: preventive therapy; disease; predicted impact; tuberculosis ... See more keywords