IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression
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DOI: 10.1172/jci.insight.157509
Abstract: The ectonucleotidase CD39 functions as a checkpoint in purinergic signaling on effector T cells. By depleting eATP and initiating the generation of adenosine, it impairs memory cell development and contributes to T cell exhaustion, thereby… read more here.
Keywords: cell; adenosine mediated; expression; prevents adenosine ... See more keywords