Abstract 4416: IL-1 blockade prevents cardiac toxicity and improves immunotherapy efficacy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4416
Abstract: Background: Immune checkpoint blockers (ICBs) have revolutionized cancer treatment, but they are often associated with severe immune related adverse events (irAEs). These severe irAEs are more often seen in patients with obesity or concomitantly treated… read more here.
Keywords: prevents cardiac; blockade; cardiac toxicity; blockade prevents ... See more keywords
Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts
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DOI: 10.1159/000493672
Abstract: Background/Aims: Histone deacetylases (HDACs) play a critical role in the regulation of gene transcription, cardiac development, and diseases. The aim of this study was to investigate whether the inhibition of HDACs improves cardiac remodeling and… read more here.
Keywords: myocardial infarction; cardiac remodeling; autophagic flux; histone deacetylases ... See more keywords