Target-mediated exposure enhancement: a previously unexplored limit of TMDD
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-020-09693-1
Abstract: Target-mediated drug disposition (TMDD) is often observed for targeted therapeutics, and manifests as decreases in clearance and volume of distribution with increasing dose as a result of saturable, high affinity target binding. In the present… read more here.
Keywords: previously unexplored; exposure enhancement; mediated exposure; target ... See more keywords
Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.10.036
Abstract: A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug donepezil, which… read more here.
Keywords: previously unexplored; alzheimer disease; disease; chemical space ... See more keywords