Deletion of PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1) worsens salt sensitive hypertension and kidney damage in Dahl S rats
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DOI: 10.1152/physiol.2023.38.s1.5731416
Abstract: Prex1 (Phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1) is a Rac-specific guanine nucleotide exchanging factor and an integrator of signaling between Rac1 and protein kinase A (PKA). Both Rac1 and PKA are involved in pathways associated with… read more here.
Keywords: hypertension; prex1; physiology; salt sensitive ... See more keywords