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   Articles with "prg4" as a keyword



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Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model.

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recommendations! Published in 2018 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2018.05.008

Abstract: BACKGROUND AND AIMS Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. Therefore, the impact of Prg4 deficiency on macrophage function in vitro… read more here.

Keywords: formation; atherosclerotic lesion; macrophage; prg4 ... See more keywords
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Surface-Functionalized Model Contact Lenses with a Bioinspired Proteoglycan 4 (PRG4)-Grafted Layer.

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recommendations! Published in 2018 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.8b09755

Abstract: Ocular dryness and discomfort are the primary reasons for the discontinuation of contact lens wear. This is mainly due to poorly hydrated contact lens surfaces and increased friction, particularly at the end of the day… read more here.

Keywords: surface; model; spectroscopy; contact ... See more keywords
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Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes

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recommendations! Published in 2022 at "PLOS ONE"

DOI: 10.1371/journal.pone.0267921

Abstract: Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial fluid viscosity,… read more here.

Keywords: endogenous production; hyaluronan prg4; cyclic loading; concentration ... See more keywords
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Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.990861

Abstract: The size, conformation, and organization of the glycosaminoglycan hyaluronan (HA) affect its interactions with soluble and cell surface-bound proteins. HA that is induced to form stable networks has unique biological properties relative to unmodified soluble… read more here.

Keywords: tsg; crosslinking tsg; heparan sulfate; protein ... See more keywords
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Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in Prg4 Null Mice

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23084245

Abstract: Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome leads to diarthrodial joint arthropathy and is caused by the absence of lubricin (proteoglycan 4—PRG4), a surface-active mucinous glycoprotein responsible for lubricating articular cartilage. In this study, mice lacking the orthologous… read more here.

Keywords: injection; quadruped gait; mice; rhprg4 ... See more keywords