Dietary flavonoid narirutin as a prospective antagonist of oncogenic pri/pre‐microRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7367
Abstract: MicroRNAs (miRNAs) are involved in cancer progression via translational degradation in a sequence‐specific manner of the 3′‐untranslated region (3′UTR) of messenger RNA (mRNA). The involvement of miRNA in the biological progression of various cancer types… read more here.
Keywords: pri mir; kcal mol; pri; pre ... See more keywords
Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires
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DOI: 10.1016/j.celrep.2018.12.054
Abstract: SUMMARY MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studied the… read more here.
Keywords: pri mir; cleavage; drosha cleavage; target ... See more keywords
Polymorphisms of pri-miR-219-1 are associated with the susceptibility and prognosis of non-small cell lung cancer in a Northeast Chinese population.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17035
Abstract: Occurrence and development of non-small cell lung cancer (NSCLC) is a complex process affected both by gene and environment. Single nucleotide polymorphisms (SNPs) in microRNAs' (miRNAs) biogenesis influenced the expression of mature miRNAs, further had… read more here.
Keywords: mir 219; polymorphisms pri; pri mir; lung cancer ... See more keywords
Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in Human and Drosophila
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DOI: 10.3390/ijms23105764
Abstract: MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed… read more here.
Keywords: pri mir; human drosophila; pri mirnas; expression ... See more keywords