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   Articles with "pri mirna" as a keyword



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Artificial miRNAs as therapeutic tools: Challenges and opportunities

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recommendations! Published in 2021 at "Wiley Interdisciplinary Reviews: RNA"

DOI: 10.1002/wrna.1640

Abstract: RNA interference (RNAi) technology has been used for almost two decades to study gene functions and in therapeutic approaches. It uses cellular machinery and small, designed RNAs in the form of synthetic small interfering RNAs… read more here.

Keywords: challenges opportunities; artificial mirnas; pri mirna; therapeutic tools ... See more keywords
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Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2018.12.054

Abstract: SUMMARY MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studied the… read more here.

Keywords: pri mir; cleavage; drosha cleavage; target ... See more keywords
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The association of pri-miRNA- 26a1 rs7372209 polymorphism and Preeclampsia susceptibility

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recommendations! Published in 2019 at "Clinical and Experimental Hypertension"

DOI: 10.1080/10641963.2018.1469643

Abstract: ABSTRACT MicroRNAs (miRNAs) are a class of noncoding small RNAs which regulate gene expression through post-transcriptional repression or degradation of messenger RNA. They play very important roles in various biological processes including growth, differentiation, and… read more here.

Keywords: susceptibility; mirna 26a1; 26a1 rs7372209; pri mirna ... See more keywords
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SRSF3 recruits DROSHA to the basal junction of primary microRNAs.

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recommendations! Published in 2018 at "RNA"

DOI: 10.1261/rna.065862.118

Abstract: The Microprocessor complex, consisting of an RNase III DROSHA and the DGCR8 dimer, cleaves primary microRNA transcripts (pri-miRNAs) to initiate microRNA (miRNA) maturation. Pri-miRNAs are stem-loop RNAs, and ∼79% of them contain at least one… read more here.

Keywords: pri mirnas; srsf3 recruits; pri mirna; recruits drosha ... See more keywords