Dysregulation of microRNA expression in diabetic skin.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.04.009
Abstract: BACKGROUND Clinical skin manifestations are common in diabetes; however, molecular mechanisms underlying such defects are largely unknown. Several findings indicate a role for microRNAs (miRNAs) in skin homeostasis. OBJECTIVE To investigate whether miRNA expression is… read more here.
Keywords: pri mirnas; diabetic skin; skin; expression ... See more keywords
Orientation of Human Microprocessor on Primary MicroRNAs.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00944
Abstract: Single-stranded microRNAs (miRNAs) regulate gene expression by triggering mRNA degradation and/or inhibiting mRNA translation. miRNAs play important roles in various critical cellular processes and are associated with numerous human diseases, including cancer and neurodegenerative diseases.… read more here.
Keywords: pri mirnas; orientation; orientation human; human microprocessor ... See more keywords
Primary transcript of miR858 encodes regulatory peptide and controls flavonoid biosynthesis and development in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2020 at "Nature plants"
DOI: 10.1038/s41477-020-00769-x
Abstract: MicroRNAs (miRNAs) are processed products of primary miRNAs (pri-miRNAs) and regulate the target gene expression. Though the regulatory roles of the several mature plant miRNAs have been studied in detail, the functions of other regions… read more here.
Keywords: pri mirnas; primary transcript; mipep858a; arabidopsis ... See more keywords
R-loops at microRNA encoding loci promote co-transcriptional processing of pri-miRNAs in plants.
Sign Up to like & getrecommendations! Published in 2022 at "Nature plants"
DOI: 10.1038/s41477-022-01125-x
Abstract: In most organisms, the maturation of nascent RNAs is coupled to transcription. Unlike in animals, the RNA polymerase II (RNAPII) transcribes microRNA genes (MIRNAs) as long and structurally variable pri-miRNAs in plants. Current evidence suggests… read more here.
Keywords: promote transcriptional; pri mirnas; processing; mirnas plants ... See more keywords
SWI2/SNF2 ATPase CHR2 remodels pri-miRNAs via Serrate to impede miRNA production
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0135-x
Abstract: Chromatin remodelling factors (CHRs) typically function to alter chromatin structure. CHRs also reside in ribonucleoprotein complexes, but little is known about their RNA-related functions. Here we show that CHR2 (also known as BRM), the ATPase… read more here.
Keywords: pri mirnas; atpase; mirna accumulation; chr2 ... See more keywords
PPMS: A framework to Profile Primary MicroRNAs from Single-cell RNA-sequencing datasets
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac419
Abstract: Abstract Motivation Single-cell/nuclei RNA-sequencing (scRNA-seq) technologies can simultaneously quantify gene expression in thousands of cells across the genome. However, the majority of the noncoding RNAs, such as microRNAs (miRNAs), cannot currently be profiled at the… read more here.
Keywords: cell; rna sequencing; pri mirnas; profile ... See more keywords
SRSF3 recruits DROSHA to the basal junction of primary microRNAs.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.065862.118
Abstract: The Microprocessor complex, consisting of an RNase III DROSHA and the DGCR8 dimer, cleaves primary microRNA transcripts (pri-miRNAs) to initiate microRNA (miRNA) maturation. Pri-miRNAs are stem-loop RNAs, and ∼79% of them contain at least one… read more here.
Keywords: pri mirnas; srsf3 recruits; pri mirna; recruits drosha ... See more keywords
Defining Transcriptional Regulatory Mechanisms for Primary let-7 miRNAs
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0169237
Abstract: The let-7 family of miRNAs have been shown to control developmental timing in organisms from C. elegans to humans; their function in several essential cell processes throughout development is also well conserved. Numerous studies have… read more here.
Keywords: mechanisms primary; pri mirnas; defining transcriptional; regulatory mechanisms ... See more keywords
SRSF7 and SRSF3 depend on RNA sequencing motifs and secondary structures to regulate Microprocessor
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201779
Abstract: Microprocessor cleaves pri-miRNAs to produce miRNAs. SRSF7 and SRSF3 interact with specific RNA elements in pri-miRNAs to modulate the cleavage of Microprocessor, thereby regulating miRNA biogenesis. Human Microprocessor cleaves pri-miRNAs to initiate miRNA biogenesis. The… read more here.
Keywords: pri mirnas; srsf7 srsf3; cleavage; microprocessor ... See more keywords
The Essentials on microRNA-Encoded Peptides from Plants to Animals
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020206
Abstract: Primary transcripts of microRNAs (pri-miRNAs) were initially defined as long non-coding RNAs that host miRNAs further processed by the microRNA processor complex. A few years ago, however, it was discovered in plants that pri-miRNAs actually… read more here.
Keywords: plants animals; pri mirnas; microrna encoded; essentials microrna ... See more keywords
Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in Human and Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105764
Abstract: MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed… read more here.
Keywords: pri mir; human drosophila; pri mirnas; expression ... See more keywords