p53 reactivating small molecule PRIMA‑1MET/APR‑246 regulates genomic instability in MDA‑MB‑231 cells.
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DOI: 10.3892/or.2022.8296
Abstract: Pharmacological reactivation of tumor‑suppressor protein p53 has acted as a promising strategy for more than 50% of human cancers that carry a non‑functional mutant p53 (mutp53). p53 plays a critical role in preserving genomic integrity… read more here.
Keywords: genomic instability; apr 246; p53; mda 231 ... See more keywords